Correlation between nuclear grade and biological prognostic variables in invasive breast cancer

Breast Cancer : the Journal of the Japanese Breast Cancer Society
Q YangK Kakudo

Abstract

Grading of carcinomas is an estimation of differentiation. Nuclear grading is the cytological evaluation of tumor nuclei in comparison with the nuclei of normal mammary epithelial cells. Because nuclear grading does not involve an assessment of the growth pattern of the tumor, it applies not only to invasive ductal carcinoma but also to other subtypes of breast carcinoma. A total of 215 primary breast carcinomas obtained from the Affiliated Kihoku Hospital of Wakayama Medical College were enrolled in our present study. Nuclear grade was evaluated according to the criteria of the National Surgical Adjuvant Study of Breast Cancer (NSAS-B) protocol. Immunohistochemistry was also performed to determine Bcl-2, p53, c-erbB-2, estrogen receptor (ER) and MIB-1 expression in paraffin-embedded tissues for all cases. Thirty-two (14.9%) of the patients were graded as 1,124 (57.7%) as 2, and 59 (27.4%) as 3. Nuclear grade displayed a negative correlation with Bcl-2 expression (r=-0.308, p<0.0001), and a positive correlation with c-erbB-2 overexpression (r= 0.172, p=0.0117) and tumor proliferative index labeling by MIB-1 (r=0.485, p<0.0001). These results imply that nuclear grade is related to the characteristics of tumor biology, indicating...Continue Reading

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Citations

Feb 6, 2009·Pathology Oncology Research : POR·Rachel E EllsworthCraig D Shriver
Oct 11, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kyuichi KadotaPrasad S Adusumilli
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Nov 17, 2020·Frontiers in Veterinary Science·Patrícia de Faria LainettiCarlos Eduardo Fonseca-Alves
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Patrícia F LainettiFabiana F Souza

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