Abstract
Mutations in the p53 tumour suppressor gene and amplification of the cyclin D1 (CCND1) oncogene have been commonly reported in various malignancies. In the present study of 39 squamous cell carcinomas of the head and neck, p53 mutations were manifest in 11 (28%) of the cases, whereas CCND1 amplification was seen in 6 (16%) of 37 analysed tumours. The 10 mutations occurring in coding sequences of p53 were found in exon 5 (4 cases), exon 6 (3 cases),f and exon 8 (3 cases). No mutation was found in exon 7. Eight of the 10 exon nucleotide substitutions were missense mutations and two were nonsense mutations. All six tumours with CCND1 amplification also had p53 mutations, while an additional five tumours manifested p53 mutations in the absence of CCND1 amplification. There was a statistically significant positive correlation between these two gene alterations. This raises the possibility that mutation of p53 precedes CCND1 amplification in carcinogenesis.
References
Dec 2, 1992·International Journal of Cancer. Journal International Du Cancer·E SakaiN Tsuchida
Aug 21, 1992·Cell·B Vogelstein, K W Kinzler
Jul 5, 1991·Science·M HollsteinC C Harris
Jun 6, 1991·Nature·A J LevineC A Finlay
Jan 1, 1995·Virchows Archiv : an International Journal of Pathology·V GorgoulisC Kittas
Mar 1, 1995·European Journal of Cancer. Part B, Oral Oncology·W A YeudallS S Prime
Apr 1, 1993·European Journal of Cancer. Part B, Oral Oncology·D SaranathM G Deo
Nov 1, 1994·International Journal of Cancer. Journal International Du Cancer·L XuR S Chaganti
Nov 15, 1994·International Journal of Cancer. Journal International Du Cancer·L D WangC S Yang
Jul 15, 1994·Science·P CairnsD Sidransky
Jul 15, 1994·Cell·H Toyoshima, T Hunter
Apr 15, 1994·Science·A KambM H Skolnick
Nov 19, 1993·Cell·J W HarperS J Elledge
Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Dec 16, 1993·Nature·Y XiongD Beach
Dec 16, 1993·Nature·M SerranoD Beach
Oct 28, 1993·The New England Journal of Medicine·C C Harris, M Hollstein
Citations
Apr 5, 2000·Head & Neck·P CapaccioL Pignataro
Jun 16, 2001·International Journal of Cancer. Journal International Du Cancer·Y DongM Tokuda
Dec 24, 2005·Apoptosis : an International Journal on Programmed Cell Death·Manuel Rieber, Mary Strasberg Rieber
Apr 6, 2004·Oral Oncology·Emma NiméusMårten Fernö
Mar 13, 2014·Oral Oncology·Iman SalahshourifarRosnah Binti Zain
Aug 9, 2002·Oral Oncology·H GotoS Yanagisawa
Jan 6, 2000·Oral Oncology·D SaranathA R Mehta
Jan 25, 2000·Oral Oncology·J A RegeziI O Ng
Apr 4, 2000·Oral Oncology·H MinetaM Dictor
Mar 31, 2009·Oncogene·S S KwekD G Albertson
Apr 13, 2005·Oncogene·Antoine M SnijdersDonna G Albertson
Aug 28, 2012·Journal of Oral and Maxillofacial Pathology : JOMFP·Uma SwaminathanKannan Ranganathan
Jun 18, 2004·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Chung-Ji LiuYong-Kie Wong
Nov 1, 2010·Journal of Investigative and Clinical Dentistry·Arti MewaraShivkumar D Chavhan
Jun 9, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Ya-Sian ChangJan-Gowth Chang
Aug 5, 2008·Oral Oncology·Patrick K HaDavid Sidransky
Mar 15, 2006·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Md Golam SabbirChinmay Kumar Panda
Jun 22, 1999·British Journal of Cancer·T MishinaY Kawakami