Correlation between pain severity and levels of anxiety and depression in osteoarthritis patients: a systematic review and meta-analysis.

Diana Fonseca-RodriguesFilipa Pinto-Ribeiro


Osteoarthritis (OA) is a chronic degenerative musculoskeletal disease that causes articular damage and chronic pain, with a prevalence of up to 50% in individuals >60 years of age. Patients suffering from chronic painful conditions, including OA, also frequently report anxiety or depression. A systematic review and meta-analysis were performed to assess the correlation between pain severity and depressive and anxious symptomatology in OA patients. A systematic search was conducted using four databases (PubMed, Medline, Scopus, and Web of Science) from inception up to 14 January 2020. We included original articles evaluating pain severity and anxiety and/or depression severity in OA-diagnosed patients. Detailed data were extracted from each study, including patients' characteristics and pain, anxiety, and depression severity. When available, the Pearson correlation coefficient between pain and depression severity and pain and anxiety severity was collected, and a meta-analysis of random effects was applied. This systematic review included 121 studies, with a total of 38 085 participants. The mean age was 64.3 years old, and the subjects were predominantly female (63%). The most-used scale to evaluate pain severity was the Wester...Continue Reading


Apr 10, 1999·Osteoarthritis and Cartilage·P CreamerM C Hochberg
Feb 29, 2000·The Western Journal of Medicine·J Turner, B Kelly
Dec 11, 2002·Social Science & Medicine·Aurora M Sherman
Jul 3, 2004·Clinical Orthopaedics and Related Research·Farshid GuilakJ Brice Weinberg
Apr 2, 2005·Nature Reviews. Drug Discovery·Heike A WielandKarl A Rudolphi
Jun 28, 2005·Osteoarthritis and Cartilage·Velandai K SrikanthGraeme Jones
Jun 30, 2005·Arthritis and Rheumatism·Stephen P MessierPaul DeVita
Feb 8, 2006·Arthritis and Rheumatism·Monica R MalySandra J Olney
Oct 17, 2006·BMJ : British Medical Journal·Marta BuszewiczAndy Haines
Jan 9, 2007·Osteoarthritis and Cartilage·A K LangeB Vanwanseele
Mar 7, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Cathleen J AppeltSaid A Ibrahim
May 3, 2008·BMC Musculoskeletal Disorders·J Denise PowerGillian A Hawker
Jul 26, 2008·Clinical Rheumatology·Kevin W ChenLeonard H Sigal
Nov 26, 2008·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Brendt P ParrishMary C Davis
Dec 9, 2008·The Medical Clinics of North America·David J HunterFrancis J Keefe
Feb 24, 2009·Arthritis Research & Therapy·David T Felson
Mar 4, 2009·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Natalia E MoroneDebra K Weiner
Jul 9, 2009·Journal of Clinical Nursing·Ai-Fu ChiouHsiao-Yun Huang
Jul 9, 2009·Clinical Orthopaedics and Related Research·Daniel L RiddleXiangrong Kong
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Oct 31, 2009·Arthritis and Rheumatism·Chenchen WangTimothy McAlindon
Nov 6, 2009·Archives of Physical Medicine and Rehabilitation·Kristen A ScopazG Kelley Fitzgerald
Feb 5, 2010·Best Practice & Research. Clinical Rheumatology·A Shane Anderson, Richard F Loeser
Jan 1, 2009·Journal of Rehabilitation Research and Development·Daniel PossleyEileen G Collins
Jul 28, 2010·Arthritis Care & Research·Gillian A HawkerWendy Lou
Aug 12, 2010·Clinics in Geriatric Medicine·Yuqing Zhang, Joanne M Jordan
Sep 3, 2010·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Rajiv GandhiNizar N Mahomed
Mar 18, 2011·The Journal of Bone and Joint Surgery. American Volume·Ki Woong KimTae Kyun Kim
Mar 29, 2011·Osteoarthritis and Cartilage·J R HochmanG A Hawker
Jun 21, 2011·Lancet·Johannes W J BijlsmaFloris P J G Lafeber

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