Correlation between peripheral CA-125 levels and ovarian activity

Fertility and Sterility
A ZweersD Vandekerckhove

Abstract

Serum CA-125 concentrations were measured at three different times in normal cycles, pill-suppressed cycles, and cycles stimulated for intrauterine insemination (IUI) or oocyte retrieval, i.e., (1) during the first half of the cycle, (2) at midcycle or at the moment of oocyte retrieval, and (3) the second half of the cycle. Significant variations of serum CA-125 concentrations were not seen during the cycle in normally cycling women or in women taking oral contraceptives: mean +/- SD 28.9 +/- 13.3 U/mL and 26.9 +/- 11.3 U/mL, respectively. In patients stimulated for in vitro fertilization, luteal phase CA-125 levels (60.6 +/- 38 U/mL) were significantly higher than during stimulation (21.5 +/- 5.9 U/mL) or at oocyte retrieval (19.6 +/- 6.4 U/mL). In stimulated cycles for IUI, without laparoscopy or follicular puncture, a comparable rise of CA-125 was observed in the luteal phase (49.6 +/- 37.8 U/mL). However, in patients undergoing laparoscopic sterilization, serum CA-125 concentrations before and after laparoscopy were not significantly different (22.8 +/- 6.3 U/mL and 25 +/- 4.2 U/mL, respectively).

Citations

Feb 28, 2003·American Journal of Reproductive Immunology : AJRI·Sanja VujisićAsim Kurjak
Jul 1, 2017·BioMed Research International·Marco Aurelio Pinho OliveiraAlessandra Viviane Evangelista Demôro
Mar 3, 2012·Clinical and Experimental Reproductive Medicine·Seung Ah ChoeShin Young Moon
May 22, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Emanuela AnastasiCecilia Midulla
Sep 20, 2006·Archives of Gynecology and Obstetrics·Hasan KafaliMeral Erdem
Apr 1, 1994·European Journal of Obstetrics, Gynecology, and Reproductive Biology·I PhocasP A Zourlas

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