PMID: 9539257Apr 16, 1998Paper

Correlation between plasma clozapine concentration and heart rate variability in schizophrenic patients

Psychopharmacology
Thomas RechlinW P Kaschka

Abstract

Forty schizophrenic patients treated with 50-600 mg/day of clozapine as monotherapy and 40 normal control subjects were tested for heart rate variability (HRV) which is mediated by the vagus nerve using acetylcholine as neurotransmitter. As compared to the control subjects, the patients showed essentially reduced HRV parameters which were negatively correlated with the plasma clozapine levels. Therefore, clozapine's anticholinergic effect is correlated to the plasma clozapine level when measured by the decrease of HRV. We suggest that HRV data might be useful as a predictor for plasma clozapine levels.

Citations

Jan 31, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jong-Hoon KimYong Sik Kim
Sep 6, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Marie Jeanne HaackPhilippe A E G Delespaul
Aug 28, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M I LossiusL Gjerstad
Sep 17, 2011·European Psychiatry : the Journal of the Association of European Psychiatrists·A BirkhoferG Schmidt
Apr 29, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jae Seung ChangYong Min Ahn
Sep 27, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·N A Buckley, P Sanders
Nov 2, 2019·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Wookyoung JungSeung-Hwan Lee
Apr 20, 2018·Frontiers in Neuroscience·Jessica W Y YuenAlasdair M Barr

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