PMID: 9170414Apr 15, 1997Paper

Correlation between plasma HIV-1 RNA levels and the rate of immunologic decline

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
R IulianoL Ceccherini-Nelli

Abstract

To determine the influence of HIV-1 replication on immunologic decline and clinical outcome, we quantified the HIV-1 plasma viral load in 20 patients at different times over a mean period of 10.8 months. Quantitation was performed by branched DNA signal amplification (bDNA) and p24 antigenemia. Immunologic status was assessed through beta 2-microglobulin and CD4+ cell count determinations. CD4+ cell decline was expressed as a slope of the regression line constructed by the logarithms of CD4+ cell count observations. Mean values of plasma viral load were correlated with CD4+ cell decline and mean beta 2-microglobulin levels. Significant correlation was observed between plasma viral load quantified by the bDNA technique and CD4+ cell decline. No significant correlation was observed between plasma viral load quantified by p24 antigenemia and CD4+ cell decline. A significant correlation was observed between plasma viral load and beta 2-microglobulin levels. Immunologic decline was better predicted from HIV-1 RNA levels than from the CD4+ cell count. Significantly higher plasma viral load was observed in patients who had clinical progression of HIV-1 infection. Thus, HIV-1 plasma viral load quantified by a highly reliable technique ...Continue Reading

References

Sep 1, 1991·Journal of Medical Virology·S O'SheaJ E Banatvala
Dec 14, 1989·The New England Journal of Medicine·R W CoombsL Corey
Dec 14, 1989·The New England Journal of Medicine·D D HoM Alam
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·O J CohenR T Steigbigel
Apr 15, 1995·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·C PachlB Irvine
Apr 15, 1995·Annals of Internal Medicine·J W MellorsP Gupta
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·K SakselaD Baltimore

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Citations

Feb 9, 1999·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·I T Prud'hommeE W Rud
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·R A ArnaoutM A Nowak
Sep 22, 2007·Computer Methods and Programs in Biomedicine·Alberto LandiLuca Ceccherini-Nelli
Jul 2, 2005·AIDS Research and Human Retroviruses·Shabbar JaffarHilton Whittle
Feb 24, 1999·AIDS Research and Human Retroviruses·B ParekhR Respess
Sep 24, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Lily NguyenDale J Hu
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohamed ElrefaeiHuyen Cao

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