Correlation between reticulum ribosome-binding protein 1 (RRBP1) overexpression and prognosis in cervical squamous cell carcinoma.

Bioscience Trends
Jiaqi ZhuFanling Meng

Abstract

Our purpose was to evaluate the correlation between endoplasmic reticulum ribosomal binding protein 1 (RRBP1) expression in cervical squamous cell carcinoma (CSCC) and poor patient prognosis. RRBP1 is a nascent transporter that is situated on the rough endoplasmic reticulum (ER). It adjusts to the secretion of proteins in cells and alleviates ER stress, thus stimulating cell proliferation. An immunohistochemical (IHC) study was conducted to detect the expression level of RRBP1 on 96 CSCC tissue samples. Western blot and Quantitative real-time polymerase chain reaction (qRT-PCR) were performed to compare the expression levels of RRBP1 in cervical squamous cell carcinoma with healthy cervical tissues. An overexpression of RRBP1 was observed in CSCC tissues, and the expression level was associated with FIGO stage (Stage I vs. II: 52.6% vs. 74.1%, p = 0.030), and lymph node metastasis (No vs. Yes: 61.5% vs. 92.3%, p = 0.031) but not patient age and tissue differentiation. Univariate survival analysis indicated that prognosis was associated with the expression level of RRBP1 and tissue differentiation and lymph node metastasis. Analysis of the multi-factor survival Cox model proved that RRBP1 was an independent prognostic factor. In...Continue Reading

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