Correlation between Ribosome Biogenesis and the Magnitude of Hypertrophy in Overloaded Skeletal Muscle

PloS One
Satoshi NakadaNaokata Ishii

Abstract

External loads applied to skeletal muscle cause increases in the protein translation rate, which leads to muscle hypertrophy. Although some studies have demonstrated that increases in the capacity and efficiency of translation are involved in this process, it remains unclear how these two factors are related to the magnitude of muscle hypertrophy. The present study aimed to clarify the roles played by the capacity and efficiency of translation in muscle hypertrophy. We used an improved synergist ablation in which the magnitude of compensatory hypertrophy could be controlled by partial removal of synergist muscles. Male rats were assigned to four groups in which the plantaris muscle was unilaterally subjected to weak (WK), moderate (MO), middle (MI), and strong (ST) overloading by four types of synergist ablation. Fourteen days after surgery, the weight of the plantaris muscle per body weight increased by 8%, 22%, 32% and 45%, in the WK, MO, MI and ST groups, respectively. Five days after surgery, 18+28S rRNA content (an indicator of translational capacity) increased with increasing overload, with increases of 1.8-fold (MO), 2.2-fold (MI), and 2.5-fold (ST), respectively, relative to non-overloaded muscle (NL) in the WK group. r...Continue Reading

References

Mar 1, 1968·The Journal of Cell Biology·A L Goldberg
May 1, 1995·Physiology & Behavior·T Tamaki, S Uchiyama
Feb 9, 1996·The Journal of Biological Chemistry·R D HannanL I Rothblum
Aug 13, 1999·Journal of Applied Physiology·R R RoyV R Edgerton
Nov 5, 1999·Trends in Biochemical Sciences·J R Warner
Sep 13, 2002·American Journal of Physiology. Cell Physiology·Gregory R AdamsKenneth M Baldwin
Oct 24, 2002·Clinical Orthopaedics and Related Research·Gustavo A NaderKaryn A Esser
Aug 5, 2005·American Journal of Physiology. Cell Physiology·Gustavo A NaderKaryn A Esser
Mar 17, 2006·The EMBO Journal·Sarah J GoodfellowRobert J White
Jun 7, 2007·Current Biology : CB·Sander Granneman, David Tollervey
Sep 18, 2007·European Journal of Applied Physiology·Gerasimos TerzisEva Blomstrand
May 19, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Stuart M Phillips
Sep 14, 2010·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Sander F T van der MeerHans Degens
Dec 29, 2010·Journal of Proteome Research·Charlotte Welinder, Lars Ekblad
Jun 17, 2011·Journal of Cellular Physiology·Masanao MachidaTohru Takemasa
Sep 29, 2011·The Journal of Physiology·Craig A GoodmanTroy A Hornberger
Dec 23, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thomas ChaillouXavier Bigard
Mar 10, 2012·American Journal of Physiology. Cell Physiology·Ferdinand von WaldenGustavo A Nader
Mar 27, 2012·Current Opinion in Pharmacology·Lukas G Weigl
Apr 21, 2012·Journal of Applied Physiology·Cameron J MitchellStuart M Phillips
Mar 21, 2013·Journal of Molecular and Cellular Cardiology·Ze ZhangChristopher G Proud
Jul 23, 2013·Journal of Applied Physiology·Thomas ChaillouJohn J McCarthy
Oct 17, 2013·PloS One·Cameron J MitchellStuart M Phillips
Mar 8, 2014·Journal of Cellular Physiology·Thomas ChaillouJohn J McCarthy
May 15, 2015·American Journal of Physiology. Endocrinology and Metabolism·Vandre C FigueiredoAnthony J Blazevich

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Citations

Dec 8, 2017·Journal of Cachexia, Sarcopenia and Muscle·Martin ConnollyPaul R Kemp
Jul 29, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bradley S GordonScot R Kimball
May 12, 2017·Cold Spring Harbor Perspectives in Medicine·Marcas M BammanGregory R Adams
Dec 13, 2018·Physiology·Vandré Casagrande Figueiredo, John J McCarthy
Jan 12, 2019·Exercise and Sport Sciences Reviews·Hyo-Gun KimGustavo A Nader
Apr 11, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Björn HanssonTommy R Lundberg
Jun 21, 2019·Journal of Applied Physiology·Ferdinand von Walden
May 3, 2016·Exercise and Sport Sciences Reviews·Yuan WenJohn J McCarthy
Dec 19, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael D RobertsAndreas N Kavazis
Jul 17, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Logan A PendergrastDavid P Ferguson
Aug 5, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hannah CrosslandPhilip J Atherton
Apr 14, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Ferdinand Von WaldenKevin A Murach
Jan 7, 2019·European Journal of Applied Physiology·Luke A OlsenAndrew C Fry
May 21, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tommy R LundbergRodrigo Fernandez-Gonzalo
Sep 12, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Vandre Casagrande Figueiredo
Oct 15, 2020·American Journal of Physiology. Cell Physiology·David C HughesAdam P Sharples
May 19, 2021·The Journal of Experimental Biology·Satoru Ato, Riki Ogasawara
Apr 30, 2021·The Journal of Physiology·Vandré C FigueiredoFerdinand von Walden
Jul 2, 2021·Cellular and Molecular Life Sciences : CMLS·Vandré Casagrande Figueiredo, John J McCarthy

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