Correlation between selected angiogenic markers and prognosis in pediatric adrenocortical tumors: Angiogenic markers and prognosis in pediatric ACTs

Journal of Pediatric Surgery
André Ivan Bradley dos Santos DiasSimone de Campos Vieira Abib

Abstract

Pediatric adrenocortical tumor (ACT) remains a challenging disease. Tumor weight and disease stage are still the most used indicators to prognosis and guidance of clinical decisions. Histology has not added meaningful data for risk stratification and management. ACT is metabolically active, highly vascularized, locally invasive and has the propensity to produce distant metastasis. Our objective was to correlate the expression of vascular endothelial growth factor (VEGF) and intratumoral microvessel density (MVD) with clinical and prognostic aspects in pediatric ACT. In 27 tumors, immunohistochemical expression of VEGF, CD105 (endoglin) and CD34 was analyzed. MVD was determined by CD34 and CD105 antibodies. MVD and VEGF expression was correlated with clinical characteristics and outcome. Normal pediatric glands were used as controls. Endoglin MVD was significantly higher and CD34 MVD was significantly lower in ACT than control. The VEGF expression did not differ between groups. Cytoplasmic staining for endoglin was correlated with hypertension in ACT. Endoglin MVD greater than 1 mv/field, CD34 MVD less than 32 mv/field and VEGF expression levels above 4.8% were associated with clinical and biological indicators of poor prognosis...Continue Reading

References

Dec 16, 1992·Journal of the National Cancer Institute·N WeidnerG Gasparini
Jul 1, 1992·European Journal of Pediatrics·L Schweigerer, T Fotsis
Apr 1, 1987·The Journal of Pathology·W D ThompsonJ G Simpson
Mar 1, 1989·The American Journal of Surgical Pathology·L M WeissA L Vickery
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M Hotta, A Baird
Mar 1, 1984·The American Journal of Surgical Pathology·L M Weiss
Mar 2, 1994·Journal of the National Cancer Institute·J M WangL al-Nakib
Jun 1, 1993·Journal of Pediatric Surgery·C C SabbagaD Blucher
May 28, 1993·International Journal of Cancer. Journal International Du Cancer·J M WangR D Hunter
Jun 1, 1996·The Journal of Cell Biology·P LastresC Bernabéu
Jul 1, 1996·The Journal of Pathology·S B FoxA L Harris
Mar 1, 1997·Histopathology·S B Fox
Feb 9, 1999·Medical and Pediatric Oncology·C TeinturierP F Bougnères
Jul 26, 2000·Obstetrics and Gynecology·C A BrewerM E McAsey
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·R C RibeiroR Sandrini
Dec 18, 2002·American Journal of Physiology. Endocrinology and Metabolism·Christine MalletIsabelle Vilgrain
Jun 24, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Reda S SaadJan F Silverman
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E MichalkiewiczR C Ribeiro
Oct 1, 2004·The Journal of Thoracic and Cardiovascular Surgery·Masaya TamuraGo Watanabe
Mar 12, 2005·Arquivos brasileiros de endocrinologia e metabologia·Emilia M PintoAna Claudia Latronico
Nov 11, 2005·The Journal of Urology·Silvio TucciRodolfo B Reis
Nov 14, 2006·Pathology International·Rahmawati MinhajatOsamu Tokunaga
May 20, 2008·Journal of Pediatric Surgery·Angela M HannaChristopher R Moir
Feb 24, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Nilza Nelly Fontana LopesMaria Teresa Seixas Alves
Jun 21, 2011·Journal of Pediatric Surgery·Justin D KleinChristopher B Weldon

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Citations

Mar 13, 2021·Surgical Oncology Clinics of North America·Simone de Campos Vieira Abib, Christopher B Weldon
Apr 4, 2021·International Journal of Molecular Sciences·Teresa González MuñozEnrique de Álava

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