PMID: 639829Mar 17, 1978Paper

Correlation between serum concentration and pharmacological effect on atrioventricular conduction time of the antiarrhythmic drug propafenone

European Journal of Clinical Pharmacology
K KellerH Hochrein

Abstract

Seven patients with cardiac dysrhythmias received a single, oral, therapeutically effective dose of the antiarrhythmic drug propafenone. The serum levels correlated well with changes in atrioventricular conduction times during the postabsorptive elimination phase (r = 0.8610, p less than 0.001). The mean half-lives of the serum level and the electrocardiographic effect (PQ-time) were 3.6 +/- .2 h and 3.8 +/- 0.6 h, respectively.

References

Apr 11, 1975·The American Journal of Medicine·J T Bigger
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Citations

Aug 13, 1982·European Journal of Pharmacology·E S PlatouK Landmark
Apr 1, 1990·Journal of Pharmacological Methods·A PuigdemontM Arboix
Jul 22, 1999·European Journal of Pharmacology·G ChristéJ Simurda
Jul 1, 1984·Journal of the American College of Cardiology·P J Podrid, B Lown
Mar 1, 1993·British Journal of Pharmacology·C DelgadoP Lorente
Dec 5, 1989·The American Journal of Cardiology·P Jaillon, M Drici
Aug 1, 1980·American Journal of Surgery·W C Beck
Sep 15, 1990·The American Journal of Cardiology·C J MurdockC R Kerr
Nov 14, 1984·The American Journal of Cardiology·L A SiddowayR L Woosley
Apr 15, 1988·The American Journal of Cardiology·C R KerrJ C Cooper
Apr 1, 1987·Annals of Emergency Medicine·T P McHugh, D G Perina
Sep 1, 1983·Circulation·S J ConnollyR A Winkle

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