Correlation between serum cytokeratin 19 fragment and tissue polypeptide antigen levels in patients with non-small cell lung cancer

Clinica Chimica Acta; International Journal of Clinical Chemistry
K KashiwabaraK Matsuoka

Abstract

We evaluated the correlation between serum cytokeratin 19 fragment (CYFRA 21-1) and tissue polypeptide antigen (TPA) levels in 57 non-small cell lung cancer patients. There was a significant correlation between serum CYFRA 21-1 and TPA levels for each clinical stage and TNM (T, primary tumor; N, regional lymph node involvement; M, occurrence of distant metastasis) subcategory (range of r-value = 0.809-0.998, P < 0.01). High correlations between serum CYFRA 21-1 and TPA levels were found in eight patients both before and after the surgery, in 22 patients before and after chemotherapy and in another 27 patients who could not complete the scheduled chemotherapy (range of r-value = 0.856-0.998, P < 0.0001). However the positive rate of CYFRA 21-1 was higher than that of TPA (61% vs. 53%, P < 0.05). CYFRA 21-1 would yield better diagnostic results for non-small cell lung cancers than TPA, though these tumor markers are both cytokeratin-associated tumor markers.

References

Sep 1, 1986·Journal of Surgical Oncology·H PutzkiM Jablonski
Oct 1, 1993·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·P StieberA Fateh-Moghadam
Mar 1, 1994·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·J NiklinskiJ Laudanski
Mar 1, 1994·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·W EbertE Bombardieri
Oct 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A van der GaastT A Splinter
Jan 1, 1957·International Archives of Allergy and Applied Immunology·B BJORKLUND, V BJORKLUND

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Citations

Nov 27, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·G Buccheri, D Ferrigno
Mar 21, 2002·Expert Review of Molecular Diagnostics·G Buccheri, D Ferrigno
Apr 16, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·André A NevesKevin M Brindle
May 19, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Barbara KossowskaRenata Jankowska

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