Correlation between serum IgG-2 concentrations and the antibody response to bacterial polysaccharide antigens

The New England Journal of Medicine
G R SiberG Schiffman

Abstract

We measured serum concentrations of immunoglobulin classes and IgG subclasses in 53 patients who had completed treatment for Hodgkin's disease and in 10 healthy adults. We wished to determine the relation of these classes and subclasses to the subjects' antibody responses to bacterial polysaccharide and viral protein antigens. Mean levels of the IgG-2 subclass were significantly lower in patients treated with both radiation and chemotherapy than in controls (P less than 0.05). The level of IgG-2 before immunization correlated directly with the mean antibody response both to 11 pneumococcal antigens (r = 0.71, P less than 0.001) and to the Haemophilus influenzae Type b antigen (r = 0.40, P less than 0.01). The correlation between IgG-2 concentration and pneumococcal antibody response was also significant in the 10 healthy adults ( r = 0.70, P less than 0.05). The levels of no immunoglobulin class or subclass correlated significantly with antibody responses to influenza A/Victoria/75 and A/New Jersey/76 hemagglutinins, both of which are protein antigens. The serum concentration of IgG-2 appears to provide a marker for predicting the ability to produce antibodies to polysaccharide, but not viral protein, antigens.

References

Aug 31, 1978·The New England Journal of Medicine·G R SiberG Schiffman
Mar 1, 1979·Pediatric Research·P H SchurM E Norman
Feb 1, 1979·The Journal of Pediatrics·C RothbachP Fireman
Dec 1, 1975·The Journal of Clinical Investigation·R GoldE C Gotschlich
Nov 1, 1970·The Journal of Clinical Investigation·W J YountH G Kunkel
Mar 1, 1968·The Journal of Experimental Medicine·W J YountE A Kabat
Sep 17, 1970·The New England Journal of Medicine·P H SchurF S Rosen
Aug 8, 1974·The New England Journal of Medicine·C A Alper
Jan 1, 1972·The Journal of Clinical Investigation·P AndersonD H Smith

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Citations

Jan 25, 2000·Journal of Clinical Laboratory Analysis·V L da MattaC E Corbett
Sep 1, 1996·Pediatric Pulmonology·R U SorensenL E Leiva
Jul 25, 2000·Journal of Clinical Laboratory Analysis·B K Flesch, J Neppert
Dec 1, 1988·European Journal of Pediatrics·P Bartmann, E Kleihauer
Nov 1, 1985·Journal of Clinical Immunology·P S MattilaO Mäkelä
Jul 1, 1987·Journal of Clinical Immunology·I JulkunenO Mäkelä
May 1, 1990·Journal of Clinical Immunology·J S KimD C Heiner
Jun 28, 1988·Journal of Immunological Methods·C François-GérardB Rentier
Jun 24, 1991·Journal of Immunological Methods·S RuthsT A Out
Jun 1, 1988·The Journal of Allergy and Clinical Immunology·D Y LeungR S Geha
Mar 1, 1983·Molecular Immunology·H O SarvasO Mäkelä
Mar 1, 1985·Journal of Virological Methods·G GilljamB Wahren
Apr 20, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Eki EdwardsCharlotte Cunningham-Rundles
Apr 1, 1995·The American Journal of Medicine·J Somani, R A Larson
Oct 18, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Yew Kuang ChengCatherine R Weiler
Feb 16, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·F C JavierR U Sorensen
Oct 10, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Michelle De Vera, Byung-Ho Yu
May 3, 2000·Clinical and Experimental Immunology·P D KielyD B Oliveira
May 20, 2003·Immunology and Cell Biology·Fang Fang YuanJohn S Sullivan
Mar 7, 2000·Pediatrics International : Official Journal of the Japan Pediatric Society·H WakiguchiT Kurashige
Sep 15, 2000·Pediatrics International : Official Journal of the Japan Pediatric Society·S HashiraK Yoshino
May 2, 2002·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·Y MoriyaH Tsuda
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·D C DillonS G Reed
Oct 1, 1997·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·E N Janoff, J B Rubins

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