Correlation between serum interleukin-31 level and the severity of disease in children with atopic dermatitis

Postȩpy dermatologii i alergologii
Katarzyna Siniewicz-LuzeńczykKrzysztof Zeman

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease, characterized by intense itch, typical localization and a specific image of skin lesions. Pathogenesis of pruritus in AD is not fully understood, but recent studies emphasize the role of interleukin-31 (IL-31). This relatively recently described cytokine is considered to be a potential mediator inducing pruritus in AD. To assess the correlation of serum IL-31 level and the disease severity in children with AD. Twenty-five children (16 girls and 9 boys) with AD aged from 4 months to 17 years (mean age: 4.2 years) were enrolled in the study. Disease severity in children with AD was assessed using the SCORAD (Severity SCORing of Atopic Dermatitis) index. Serum IL-31 levels were measured using ELISA with standard kits from EIAab R&D Systems. Serum IL-31 level was significantly higher in AD children than in healthy children. There was no statistic correlation between serum IL-31 level and the disease severity or itch intensity. The disease severity and itch intensity do not correlate with serum IL-31 level in children with atopic dermatitis.

Citations

Mar 11, 2015·Journal of Immunology Research·Kalina Welz-KubiakAdam Reich
Feb 2, 2017·The Journal of Dermatological Treatment·Mohammed D SaleemSteven R Feldman
Dec 20, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·E RoekevischM A Middelkamp-Hup
Jul 2, 2020·Clinical, Cosmetic and Investigational Dermatology·Khaldon BodoorMotaz A Obeidat
Dec 10, 2014·Archives of Dermatological Research·Markus MöbsStaffan Vandersee
Jun 27, 2020·Current Opinion in Allergy and Clinical Immunology·Fatih A TopalMaja Hofmann
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Aug 3, 2021·Advances in Hematology·Maria AbreuMargarida Lima

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Methods Mentioned

BETA
ELISA
biopsy
biopsies

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Statistica

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Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.