PMID: 9437405Jan 23, 1998Paper

Correlation between serum lipoprotein(a) and angiographic coronary artery disease in non-insulin-dependent diabetes mellitus

Journal of Internal Medicine
A CömlekçiG Güner

Abstract

To examine the impact of diabetic state on the concentrations of lipoprotein(a) [Lp(a)] in patients with non-insulin-dependent diabetes mellitus (NIDDM) and the correlation between angiographic coronary artery disease (CAD) and serum Lp(a) concentrations in NIDDM. In this cross-sectional study of 26 patients with NIDDM and 19 nondiabetic sex- and age-matched patients who underwent coronary angiography. CAD was assessed visually using coronary artery score (CAS), and plasma Lp(a) was measured by an enzyme-linked immunosorbent assay. The study was performed in an internal medicine clinic at a university hospital. Twenty-six age- and sex-matched patients with NIDDM and 19 control patients without diabetes. There was no significant difference between the Lp(a) concentrations of patients with NIDDM and nondiabetic subjects (P > 0.05). When patients with NIDDM were stratified by absence or presence of CAD, patients with CAD had higher levels of Lp(a) (P < 0.05). However, there was no significant correlation between the concentrations of Lp(a) and CAS (P > 0.05). Diabetic state does not have any impact on Lp(a) concentrations. Lp(a) excess seems to be atherogenic in patients with NIDDM as shown in nondiabetic patients in previous stud...Continue Reading

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Citations

Jan 27, 2006·European Journal of Clinical Investigation·C H SaelyH Drexel
Jul 20, 2006·Journal of the Royal Society, Interface·Kieron O'HaraNeil Beagrie
Apr 7, 1999·Current Opinion in Cardiology·L J SemanE J Schaefer

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