Correlation between serum neuron specific enolase and functional neurological outcome in patients of acute ischemic stroke

Annals of Indian Academy of Neurology
Sana ZaheerNishat Akhtar

Abstract

The use of biomarkers to predict stroke prognosis is gaining particular attention nowadays. Neuron specific enolase (NSE), which is a dimeric isoenzyme of the glycolytic enzyme enolase and is found mainly in the neurons is one such biomarker. This study was carried out on patients of acute ischemic stroke with the aims to determine the correlation between NSE levels on the day of admission with infarct volume, stroke severity, and functional neurological outcome on day 30. Seventy five patients of acute ischemic stroke admitted in the Department of Medicine were included in the study. Levels of NSE were determined on day 1 using the human NSE ELISA kit (Alpha Diagnostic International Texas 78244, USA). Volume of infarct was measured by computed tomography (CT) scan using the preinstalled software Syngo (version A40A) of Siemen's medical solutions (Forchheim, Germany). Stroke severity at admission was assessed using Glasgow coma scale (GCS) and functional neurological outcome was assessed using modified Rankin scale (mRS) on day 30. Statistical analysis was performed using the SPSS software for windows version 15.0 (SPSS). A positive correlation was found between concentration of NSE on day 1 and infarct volume determined by CT ...Continue Reading

References

May 1, 1988·Stroke; a Journal of Cerebral Circulation·J C van SwietenJ van Gijn
Oct 30, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·David BreaJosé Castillo
Jul 24, 2012·Clinical Biochemistry·Sergio González-GarcíaCarlos Fernández-Novales

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Citations

May 11, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Magdalena M Przybycien-Szymanska, William W Ashley
Nov 30, 2016·International Journal of Molecular Sciences·Aldo BonaventuraFabrizio Montecucco
Dec 15, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·J M MoonE J Jung
Oct 19, 2017·Korean journal of pediatrics·Dian PratamastutiDarto Saharso
Dec 12, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M P TopuzovaA A Skoromets
Jul 1, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ke LiShanChun Zhang
Oct 30, 2020·Journal of Neurotrauma·Steven T DeKoskyRonald L Hayes
Jul 16, 2021·Therapeutic Advances in Chronic Disease·Noha O MansourRehab H Werida
Nov 4, 2021·World Neurosurgery·Sauson SoldozyM Yashar S Kalani

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Methods Mentioned

BETA
ELISA

Software Mentioned

Syngo
SPSS

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