Correlation between sICAM-1 and depressive symptoms during adjuvant treatment of melanoma with interferon-alpha

Brain, Behavior, and Immunity
Martin SchaeferMarkus J Schwarz

Abstract

Interferon-alpha (IFN-alpha) treatment is frequently complicated by symptoms of depression. The mechanism by which peripherally administered IFN-alpha enters and modulates the central nervous system remains unclear. The cell adhesion molecule ICAM-1 is involved in the regulation of blood-brain barrier (BBB) permeability. ICAM-1 expression was shown to increase during IFN-alpha treatment and recently the expression of ICAM-1 on vascular endothelial cells in the brain was found to be correlated with the development of depression. We therefore hypothesized that soluble ICAM-1 may be involved in the development of IFN-alpha associated depression. In a prospective study, serum levels of soluble ICAM-1 (double sandwich ELISA test) and symptoms of depression (SDS) were measured in 48 patients with malignant melanoma before and during adjuvant IFN-alpha treatment. Both, depression scores and the serum levels of sICAM-1 significantly increased after three months of IFN-alpha treatment compared to baseline levels (p < .001). Patients who developed depression (SDS-index scores > or = 50) after three months of treatment had higher sICAM-1 levels compared to non-depressed patients. Furthermore, sICAM-1 levels were positively correlated with...Continue Reading

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Citations

Oct 12, 2007·Der Nervenarzt·N Müller, M J Schwarz
Jul 27, 2010·Neurotoxicity Research·Norbert MüllerMarkus J Schwarz
Mar 15, 2008·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Ryan J Van Lieshout, Glenda Macqueen
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Jul 13, 2006·Expert Review of Neurotherapeutics·Norbert Müller, Markus J Schwarz
Mar 20, 2019·Journal of Neuroendocrinology·Florent PittetBenjamin C Nephew
Jun 3, 2021·International Journal of Environmental Research and Public Health·Alessandra TesserAlberto Tommasini

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