Correlation between SIV Tat evolution and AIDS progression in cerebrospinal fluid of morphine-dependent and control macaques infected with SIV and SHIV

Virology
Richard J NoelAnil Kumar

Abstract

Morphine abuse has been associated with higher virus replication and accelerated disease progression in a non-human primate model of AIDS. In our previous report, we have shown that 50% of morphine-addicted macaques progress rapidly and that 2/3 of the rapid progressors exhibit severe neuropathogenesis. In this report, we examined the sequence evolution of the SIV Tat protein, known to participate in AIDS neuropathology, in the cerebrospinal fluid (CSF) of morphine-dependent and control macaques over the first 20 weeks of infection. The CSF SIV Tat evolution was found to be inversely related with disease progression, and the highly neuropathogenic inoculum clone sequence was the prevalent CSF form in rapid progressors. Divergence from the inoculum clone was significantly greater in both morphine-dependent normal progressors and control macaques than in the morphine-dependent rapid progressors. Furthermore, we also found evidence of a trend that morphine alters the type of mutation, resulting in an enhanced ratio of transitions to transversions (Ts:Tv). Rapid disease exacerbates this trend and appears to influence the distribution of nonsynonymous changes in the first exon of SIV tat, with a clear majority of mutations occurring...Continue Reading

References

Sep 1, 1991·Journal of Neurology·E ScarpiniG Scarlato
Oct 1, 1990·AIDS Research and Human Retroviruses·S P SquintoO Prakash
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S ColombiniF Wong-Staal
Jun 1, 1986·Annals of Neurology·B A NaviaR W Price
Nov 7, 1986·JAMA : the Journal of the American Medical Association·M H StolerL M Angerer
Jun 1, 1986·Annals of Neurology·B A NaviaR W Price
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·J P VartanianS Wain-Hobson
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·M A MartinezS Wain-Hobson
Jul 25, 1995·Nucleic Acids Research·M A MartínezS Wain-Hobson
Sep 30, 1993·Biochemical and Biophysical Research Communications·L F ChuangR Y Chuang
Mar 5, 1999·Journal of Neurovirology·L ZhangM Fiala
May 18, 1999·Archives of Biochemistry and Biophysics·T M Rana, K T Jeang
May 24, 2000·Journal of Neurovirology·L HudsonI Everall
Aug 9, 2002·The Journal of Biological Chemistry·Xiaojuan LiuKalipada Pahan
Oct 11, 2002·Proceedings of the National Academy of Sciences of the United States of America·Enrique GonzalezSunil K Ahuja
Oct 24, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Eric AndersonHoward E Gendelman
Oct 24, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Avi NathJadwiga T Turchan
Oct 24, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jutta K NeuenburgWolfgang Schlote
May 3, 2003·Virology·Amber D SteeleThomas J Rogers

❮ Previous
Next ❯

Citations

Jan 29, 2014·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Shaily MalikPankaj Seth
Apr 29, 2009·AIDS Research and Human Retroviruses·Vanessa Rivera-AmillAnil Kumar
Dec 17, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Vanessa Rivera-AmillAnil Kumar
Oct 24, 2007·Peptides·Richard J Bodnar
Sep 3, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Sylvia FittingKurt F Hauser

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.