Correlation between Soluble α -Klotho and Renal Function in Patients with Chronic Kidney Disease: A Review and Meta-Analysis

BioMed Research International
Qinglian WangRong Wang

Abstract

Over decades, numerous inconsistent studies are reported on the relationship between soluble α-Klotho and renal function in patients with chronic kidney disease (CKD). This study aims to perform a meta-analysis to figure out the correlations between soluble α-Klotho and renal function in patients with CKD. We searched medical and scientific literature databases, PubMed and EMBASE (from the inception to October 2017), for publications that reported studies on associations between soluble α-Klotho and renal function in patients with CKD. Only publications in English were extracted. Summary correlation coefficient (r) values were extracted from each study, and 95% confidence intervals (CIs) were calculated. Publication bias was tested, and sensitivity and subgroup analyses were performed to investigate potential heterogeneity. Of 611 studies, 9 publications with 1457 patients were included into the analysis. The following data were extracted from the literature: first author, year of publication, research region, research index, sample size, average age and Pearson or Spearman correlation coefficient, study design, the αKlotho/FGF23 assays utilized, full length, or the C-terminal fragment of FGF23. The pooled r between α-Klotho an...Continue Reading

References

Sep 24, 1999·JAMA : the Journal of the American Medical Association·P JüniM Egger
Feb 13, 2001·Biochemical and Biophysical Research Communications·N KohY Nabeshima
Apr 23, 2002·Hypertension·Haruo MitaniRyozo Nagai
Sep 3, 2002·Hearing Research·Mariko KamemoriNobuhiko Furuya
Feb 7, 2003·Journal of the American College of Cardiology·Guruprasad ManjunathMark J Sarnak
Jul 21, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Takashi ShigematsuMasafumi Fukagawa
May 27, 2005·Journal of the American Society of Nephrology : JASN·Orlando GutierrezMyles Wolf
Aug 27, 2005·Science·Hiroshi KurosuMakoto Kuro-o
Oct 6, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hidekazu SugiuraHiroshi Nihei
Feb 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yoshisuke HarunaYashpal S Kanwar
Oct 4, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Richard MarsellKenneth B Jonsson
Nov 10, 2007·The Journal of Clinical Investigation·Iddo Z Ben-DovJustin Silver
Jan 8, 2008·Biological Chemistry·Makoto Kuro-o
Jul 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Seung-Kuy ChaChou-Long Huang
Nov 22, 2008·Ageing Research Reviews·Yuhong Wang, Zhongjie Sun
Feb 24, 2009·Biochimica Et Biophysica Acta·Makoto Kuro-o
Feb 4, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tobias E Larsson
May 1, 2010·Journal of the American Society of Nephrology : JASN·Rocío CanalejoMariano Rodriguez
May 15, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ming Chang HuOrson W Moe
Jun 12, 2010·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Orlando M GutiérrezMyles Wolf
Sep 18, 2010·Journal of the American Society of Nephrology : JASN·Orlando M GutiérrezUNKNOWN CRIC Study Group
May 6, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jacques Bernheim, Sydney Benchetrit
Aug 6, 2011·Clinical and Experimental Nephrology·Hidekazu SugiuraKosaku Nitta
Mar 16, 2012·Kidney International·Guang-Huar Young, Vin-Cent Wu
Nov 7, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ivana PavikAndreas L Serra
Jan 31, 2013·European Journal of Endocrinology·Marian Christoph NeidertRené-Ludwig Bernays
Apr 2, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Hyoung Rae KimSeung Hyeok Han
Jun 4, 2013·Lancet·Vivekanand JhaChih-Wei Yang

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Citations

May 30, 2020·Journal of Pediatric Endocrinology & Metabolism : JPEM·Fariba TarhaniAlireza Nezami
Jun 18, 2020·Journal of Clinical Medicine·Charat ThongprayoonWisit Cheungpasitporn
Aug 14, 2020·Journal of Clinical Medicine·Barbara InfanteGiovanni Stallone
Aug 23, 2020·Antioxidants·Alina Podkowińska, Dorota Formanowicz
Dec 31, 2020·International Journal of Molecular Sciences·Irina LousaAlice Santos-Silva
Feb 26, 2021·Oxidative Medicine and Cellular Longevity·Ewa WojtaszekJolanta Malyszko
May 18, 2021·Frontiers in Pharmacology·Rossana FranzinGiuseppe Castellano
Jun 3, 2021·Nutrients·Ken Tsuchiya, Taro Akihisa
Aug 21, 2019·Kidney & Blood Pressure Research·Daniela PicciottoDaniela Verzola

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