Correlation between specific IgA and eosinophil numbers in the lavage fluid of patients with perennial allergic rhinitis

Allergy and Asthma Proceedings
Jeong-Hoon OhHae-Sim Park

Abstract

The mechanisms of eosinophil activation in perennial allergic rhinitis (AR) are not fully understood but may be mediated by a series of inflammatory mediators, including locally produced specific antibodies. The aim of this study was to evaluate the role of locally produced allergen-specific antibodies in the nasal lavage fluid during the recruitment of inflammatory cells in AR. Thirteen patients with AR and a positive nasal provocation test (NPT) with Dermatophagoides pteronyssinus and 10 asymptomatic subjects, sensitized to D. pteronyssinus but who had a negative NPT were enrolled. Nasal lavage fluids were collected before and at 10, 30, and 60 minutes and 3, 6, and 24 hours after the NPT. Inflammatory cells were counted, and eosinophil cationic protein (ECP) and specific immunoglobulin E (IgE), IgG, and IgA antibodies were measured by enzyme-linked immunosorbent assay. After NPT, six subjects showed early responses and seven subjects showed dual responses. The eosinophil count and ECP level in lavage fluid were significantly increased after NPT in patients with positive NPTs, and these values were significantly higher than in the negative group. The specific IgA level in lavage fluid was increased after NPT in the positive g...Continue Reading

Citations

Feb 25, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G-S ChoiH-S Park
Dec 18, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G-S ChoiH-S Park
Aug 17, 2012·Human Vaccines & Immunotherapeutics·Wayne R Thomas
Sep 8, 2010·Environmental Health : a Global Access Science Source·Theodore A MyattJames J McDevitt
Apr 5, 2011·Clinical and Experimental Otorhinolaryngology·Seung-Youp ShinHae Sim Park
Apr 30, 2016·Allergy, Asthma & Immunology Research·Ji Hye KimHae Sim Park
Oct 30, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F M CarlierC Pilette
Dec 22, 2011·American Journal of Rhinology & Allergy·Joy Hsu, Anju T Peters
Jan 27, 2019·The Annals of Otology, Rhinology, and Laryngology·Motohiko SuzukiYoshihisa Nakamura
Oct 12, 2018·Allergy, Asthma & Immunology Research·Ji Hye KimHae Sim Park

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