PMID: 9540814Apr 16, 1998Paper

Correlation between stationary phase survival and acid trehalase activity in yeast

Biochimica Et Biophysica Acta
A Roy, A K Ghosh

Abstract

The levels of two trehalose hydrolysing enzymes, acid trehalase (AT) and neutral trehalase (NT), have been investigated in Candida utilis at different stages of growth; in complete contrast to Saccharomyces cerevisiae, significant AT activity appears to be absent at all stages of growth studied in C. utilis. In addition, presence of only very low amounts of iso-aspartyl methyl transferase (IMT) activity at the onset of stationary phase and lower survival ability in early stationary phase in contrast to that of S. cerevisiae lend support to the ideas that (a) lower degree of survival of C. utilis in the stationary phase may be a direct consequence of inability to mobilise stored trehalose due to absence of intracellular AT and reduced levels of IMT activities and (b) trehalose may have a dual role vis-à-vis stress resistance in yeasts.

References

Jan 1, 1992·Annual Review of Physiology·J H CroweL M Crowe
Jan 1, 1974·Advances in Carbohydrate Chemistry and Biochemistry·A D Elbein
Apr 15, 1984·The Biochemical Journal·J Londesborough, K Varimo
Jun 1, 1993·Microbiological Reviews·M Werner-WashburneR A Singer

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