Nov 1, 2017

Correlation between STK33 and the pathology and prognosis of lung cancer

Oncology Letters
Yi LuDanrong Yang

Abstract

Correlation between the expression of STK33 and the pathology of lung cancer was investigated, to explore its effects on prognosis. Hundred and two lung cancer patients diagnosed by pathological examinations were randomly selected in Shanghai Jiao Tong University Affiliated Sixth People's Hospital from February, 2012 to February, 2017 to serve as observation group, and the tumor tissues were collected. At the same time, 19 patients with lung benign lesions were selected and lung tissues were also collected to serve as control group. RT-qPCR was used to detect the expression of STK33 mRNA in tissues. Expression levels of STK33 protein were detected and compared by SP immunohistochemistry staining and western blot analysis. Statistical analysis was performed to analyze the correlation between STK33 expression and the pathology and prognosis of lung cancer. Results of PCR showed that expression level of STK33 gene in control group was significantly lower than that in observation group (p<0.05). The expression level of STK33 mRNA in lung adenocarcinoma and squamous cell carcinoma was lower than that in lung small cell carcinoma and large cell carcinoma (p<0.05). Western blot analysis showed that the expression level of STK33 protei...Continue Reading

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Mentioned in this Paper

Real-Time Polymerase Chain Reaction
Adenocarcinoma of Lung (Disorder)
Immunohistochemistry
Lung
Tumor Tissue Sample
Western Blotting
STK33 protein, human
Recurrent Malignant Neoplasm
Small Cell Carcinoma of Lung
Carcinoma of Lung

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