Correlation between superoxide dismutase 1 and 2 polymorphisms and susceptibility to oral squamous cell carcinoma

Experimental and Therapeutic Medicine
Ying LiuLongjiang Li

Abstract

Oxidative stress is significant in numerous types of cancer. Tobacco smoke, an important risk factor for oral squamous cell carcinoma (OSCC), is able to generate reactive oxygen species (ROS) and cause oxidative DNA damage. Superoxide dismutase (SOD) is an endogenous antioxidant enzyme that is critical in limiting the oxidative burden effectively. The purpose of this study was to investigate the effects of the mitochondrial SOD2 and Cu/Zn enzyme SOD1 gene polymorphisms on the susceptibility to and clinicopathological characteristics of OSCC, as well as the synergistic effect between these gene polymorphisms and the well-known risk factor of tobacco consumption. Patients with clinically diagnosed OSCC (n=362) and healthy normal individuals (n=358) were investigated for four single nucleotide polymorphisms (SNPs; rs4880, rs5746136, rs1804450 and rs11556620) by polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing methods. Following adjustment for other confounders, no significant difference was observed in the rs5746136 SOD2 SNPs between the patients and controls. However, the incidence of the CT genotype of SOD2 SNP rs4880 was higher in the patients than in normal subjects in the additive model [C...Continue Reading

References

Sep 1, 1991·Mutation Research·B N Ames, L S Gold
Jan 1, 1988·Free Radical Biology & Medicine·J M McCord, I Fridovich
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Mar 19, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·J YangL W Oberley
Mar 21, 2002·The Lancet Oncology·P R SrinivasS Srivastava
Mar 3, 2004·Free Radical Biology & Medicine·Vuokko L Kinnula, James D Crapo
Apr 1, 2004·British Journal of Cancer·M P ColemanJ Estève
Sep 19, 2006·The International Journal of Biochemistry & Cell Biology·Marian ValkoJoshua Telser
Mar 23, 2007·Genes, Brain, and Behavior·H W WienerR C P Go
Jul 25, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Daehee KangRichard B Hayes
Oct 13, 2007·The British Journal of Oral & Maxillofacial Surgery·Peter KesslerFriedrich Wilhelm Neukam
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Mar 26, 2008·Cancer Letters·Makiya Nishikawa
Aug 7, 2008·Neuro-oncology·Preetha RajaramanPeter D Inskip
Sep 28, 2010·World Journal of Gastroenterology : WJG·Jian-Feng YiJun-Qiang Zhang
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Miluse HubackovaPavel Soucek
May 7, 2011·Journal of Oncology·Wen-Jiun LinShih-An Liu
Sep 24, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Anne M HakenewerthAndrew F Olshan
Nov 24, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Tao YuLongjiang Li
Apr 14, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Omotayo O ErejuwaMohd S Ab Wahab

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Citations

Sep 22, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shaleen Multani, Dhananjaya Saranath
Mar 31, 2015·Journal of Child Neurology·Semra SaygiFatma Belgin Ataç
Feb 11, 2018·Scientific Reports·Peter Mu-Hsin ChangChi-Ying F Huang
Nov 25, 2014·Oral Diseases·A H KesarwalaJ B Mitchell
Mar 25, 2019·Biomedical Reports·Ayca TaşMustafa GüRelık
Jul 17, 2020·Cancer Investigation·Nisha ThakurShalini Singh
Dec 17, 2015·Experimental and Therapeutic Medicine·Y I TangHaiyang Yu
Dec 2, 2015·Oncology Letters·Daniel DroguettUlrike Kemmerling
Aug 28, 2019·Journal of Cellular Biochemistry·Hetal Damani ShahSultan Pradhan
Sep 23, 2018·Pathology Oncology Research : POR·Alireza EftekhariMostafa Saadat
Aug 12, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kathiroli SujithraVeerasamy Vinothkumar

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Methods Mentioned

BETA
PCR
electrophoresis
genotyping
biopsies

Software Mentioned

SHEsis
PowerStats
NanoDrop
SPSS

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