Correlation between symptomatic improvement and quality of life in patients with reflux and dyspeptic symptoms.

Journal of Clinical Biochemistry and Nutrition
Seiji ArihiroHisao Tajiri

Abstract

We investigated the correlation between symptomatic improvement and quality of life in Japanese gastroesophageal reflux disease patients with PPI. Eighty one patients with reflux and dyspeptic symptom were enrolled. The evaluation of the symptom was used he Frequency Scale for the Symptom of GERD in 3 categories: total score of 12 questions, score related to reflux symptoms, and score related to dyspeptic symptoms and the evaluation of the quality of life was use the 8-item Short Form Health Survey in 2 categories, the physical component summary score and mental component summary score. All patients administered rabeprazole 10 mg/day for 8 weeks. We investigated the correlation between symptomatic improvement with proton pump inhibitor and quality of life. Significant symptomatic improvement was seen in the total score of 12 questions (26.7 ± 8.8 → 17.5 ± 5.9, p<0.0001), score related to reflux symptoms (14.9 ± 5.4 → 9.6 ± 3.6, p<0.0001), and score related to dyspeptic symptoms (11.8 ± 4.3 → 8.0 ± 2.9, p<0.0001). Significant improvement in quality of life was seen in the physical component summary score (47.8 ± 6.6 → 50.0 ± 5.9, p = 0.0209) and mental component summary score (47.4 ± 8.5 → 50.4 ± 5.3, p = 0.0133) with proton pum...Continue Reading

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Citations

Jan 24, 2013·Journal of Clinical Biochemistry and Nutrition·Hiroshi ShidaTetsuo Takayama
Jan 24, 2013·Journal of Clinical Biochemistry and Nutrition·Hitoshi EguchiShuichi Yamashita
Apr 4, 2017·Journal of Clinical Biochemistry and Nutrition·Takashi KawaiShinichi Nakamura

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