Abstract
The PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor gene codifies a lipid inositol 3'-phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3' kinase (PIP3-kinase)--protein kinase B/Akt signaling pathway. Recently, PIP3-kinase was involved in axon polarization, but PTEN functions in dendrites are uncertain. Using amino-terminal antibodies against the catalytic domain, we found a 34 kDa fragment of PTEN protein detected only in mouse brain tissue, present in neuron dendrites and spines of cerebral cortex, cerebellum, hippocampus and olfactory bulb. The PTEN-fragment reaches the synaptic fraction with a positive temporal correlation with synaptic stabilization in postnatal cerebellum and brain. In the weaver mutant mice, PTEN was absent only in the Purkinje cells dendrites that cannot receive the granule cells synaptic input. Furthermore, the activated p-Akt/PKB was present in axons but not in dendrites of mature neuron cells. P-Akt was also altered by the weaver mutation maintaining the inverse correlation with the PTEN-fragment in Purkinje cell dendrites. In contrast, the expression of this fragment was not affected by the staggerer mutation. Together, these re...Continue Reading
References
Jun 15, 1978·The Journal of Comparative Neurology·D M Landis, R L Sidman
Aug 22, 1975·Brain Research·C Sotelo
Oct 11, 1992·American Journal of Medical Genetics·R J GorlinB A Burke
Aug 1, 1972·The Journal of Comparative Neurology·J Altman
Oct 1, 1995·Nature Genetics·N PatilA S Peterson
Oct 1, 1995·Journal of Neuroscience Research·M RadrizzaniV P Idoyaga Vargas
Jun 5, 1998·The Journal of Biological Chemistry·T Maehama, J E Dixon
Aug 11, 1998·Nature Genetics·A Di CristofanoP P Pandolfi
Oct 20, 1998·Cell·V StambolicT W Mak
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·L C Cantley, B G Neel
Sep 24, 1999·Hippocampus·S J MizumoriS Leutgeb
Nov 11, 1999·Cell·J O LeeN P Pavletich
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·B RaughtN Sonenberg
Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·K PodsypaninaR Parsons
Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·M S NeshatC L Sawyers
Aug 30, 2001·Proceedings of the National Academy of Sciences of the United States of America·G B MillsE C Kohn
Dec 1, 2001·Nature Genetics·S A BackmanT W Mak
Dec 1, 2001·Nature Genetics·C H KwonS J Baker
Mar 2, 2002·Science·Hugo StockerErnst Hafen
Jun 8, 2002·Annual Review of Neuroscience·Kristin L WhitfordAnirvan Ghosh
Jul 19, 2002·Neuron·Annette MarkusWilliam D Snider
Aug 8, 2002·Neuron·Linnaea E OstroffKristen M Harris
Oct 9, 2002·Current Opinion in Neurobiology·Stéphanie BackmanTak Mak
Oct 9, 2002·Trends in Biochemical Sciences·Changan Jiang, Erin M Schuman
Jan 16, 2003·Cell·Song-Hai ShiYuh-Nung Jan
Aug 24, 1962·Science·R L SIDMANM M DICKIE
Citations
Feb 28, 2006·Apoptosis : an International Journal on Programmed Cell Death·Y ZhuJ Krieglstein
Aug 22, 2012·Cell Stress & Chaperones·Niubys Cayado-GutiérrezDaniel R Ciocca
Feb 12, 2013·Cell Stress & Chaperones·F Darío Cuello-CarriónDaniel R Ciocca
Apr 13, 2013·Trends in Cell Biology·Adam Naguib, Lloyd C Trotman
Aug 25, 2012·Molecular Biology of the Cell·Pan P Li, H Benjamin Peng
Aug 17, 2012·Science Signaling·Elouan TerrienNicolas Wolff
May 12, 2011·PloS One·Vera L MoncaleroMartin Radrizzani
Nov 19, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wenyu SongWilma J Friedman
Feb 6, 2014·Human Molecular Genetics·Amy E Clipperton-Allen, Damon T Page
Sep 19, 2009·Hearing Research·Su-Hua ShaJochen Schacht
Oct 26, 2007·Trends in Neurosciences·Ning ChangQi Wan
Dec 16, 2006·Neurochemistry International·Yuan ZhuJosef Krieglstein
Jan 15, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Qi-Yan CaiZhong-Xiang Yao
Jan 20, 2006·The European Journal of Neuroscience·Roxana V CostanzoMartín Radrizzani
Jul 16, 2010·The EMBO Journal·Sandra JuradoJosé A Esteban
Oct 10, 2013·Clinical Genetics·X-Y ChenY-M Wu
Nov 14, 2012·Neurological Research·Guangcheng QinJiying Zhou
Apr 29, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Amanda K TilotCharis Eng
May 6, 2006·Neuron·Chang-Hyuk KwonLuis F Parada
Feb 6, 2017·Neuroscience and Biobehavioral Reviews·S TordjmanP L Roubertoux
Jun 10, 2010·Neuroreport·Youyi DongMasaaki Tokuda
Jun 7, 2018·Scientific Reports·J V Cabral-CostaE M Kawamoto
Feb 11, 2020·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Huachao ShenXinsheng Ding
Aug 21, 2019·Cold Spring Harbor Perspectives in Medicine·Sebastian Rademacher, Britta J Eickholt
Dec 3, 2016·Frontiers in Cellular Neuroscience·Yu-Chih LinGene J Blatt
Jun 27, 2019·Cerebral Cortex·Cristina Sánchez-PuellesShira Knafo
Oct 28, 2015·Translational Neurodegeneration·Danielle D FengXiqun Chen
Feb 4, 2021·Diagnostics·Gloria LonginottiMartin Radrizzani