Correlation between synaptogenesis and the PTEN phosphatase expression in dendrites during postnatal brain development

Brain Research. Molecular Brain Research
Claudia PerandonesMartín Radrizzani

Abstract

The PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor gene codifies a lipid inositol 3'-phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3' kinase (PIP3-kinase)--protein kinase B/Akt signaling pathway. Recently, PIP3-kinase was involved in axon polarization, but PTEN functions in dendrites are uncertain. Using amino-terminal antibodies against the catalytic domain, we found a 34 kDa fragment of PTEN protein detected only in mouse brain tissue, present in neuron dendrites and spines of cerebral cortex, cerebellum, hippocampus and olfactory bulb. The PTEN-fragment reaches the synaptic fraction with a positive temporal correlation with synaptic stabilization in postnatal cerebellum and brain. In the weaver mutant mice, PTEN was absent only in the Purkinje cells dendrites that cannot receive the granule cells synaptic input. Furthermore, the activated p-Akt/PKB was present in axons but not in dendrites of mature neuron cells. P-Akt was also altered by the weaver mutation maintaining the inverse correlation with the PTEN-fragment in Purkinje cell dendrites. In contrast, the expression of this fragment was not affected by the staggerer mutation. Together, these re...Continue Reading

References

Jun 15, 1978·The Journal of Comparative Neurology·D M Landis, R L Sidman
Oct 11, 1992·American Journal of Medical Genetics·R J GorlinB A Burke
Oct 1, 1995·Journal of Neuroscience Research·M RadrizzaniV P Idoyaga Vargas
Aug 11, 1998·Nature Genetics·A Di CristofanoP P Pandolfi
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·L C Cantley, B G Neel
Sep 24, 1999·Hippocampus·S J MizumoriS Leutgeb
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·B RaughtN Sonenberg
Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·K PodsypaninaR Parsons
Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·M S NeshatC L Sawyers
Jun 8, 2002·Annual Review of Neuroscience·Kristin L WhitfordAnirvan Ghosh
Jul 19, 2002·Neuron·Annette MarkusWilliam D Snider
Oct 9, 2002·Current Opinion in Neurobiology·Stéphanie BackmanTak Mak
Oct 9, 2002·Trends in Biochemical Sciences·Changan Jiang, Erin M Schuman
Aug 24, 1962·Science·R L SIDMANM M DICKIE

❮ Previous
Next ❯

Citations

Feb 28, 2006·Apoptosis : an International Journal on Programmed Cell Death·Y ZhuJ Krieglstein
Aug 22, 2012·Cell Stress & Chaperones·Niubys Cayado-GutiérrezDaniel R Ciocca
Apr 13, 2013·Trends in Cell Biology·Adam Naguib, Lloyd C Trotman
Nov 19, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wenyu SongWilma J Friedman
Sep 19, 2009·Hearing Research·Su-Hua ShaJochen Schacht
Oct 26, 2007·Trends in Neurosciences·Ning ChangQi Wan
Jan 15, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Qi-Yan CaiZhong-Xiang Yao
Jan 20, 2006·The European Journal of Neuroscience·Roxana V CostanzoMartín Radrizzani
Apr 29, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Amanda K TilotCharis Eng
May 6, 2006·Neuron·Chang-Hyuk KwonLuis F Parada
Feb 11, 2020·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Huachao ShenXinsheng Ding
Aug 21, 2019·Cold Spring Harbor Perspectives in Medicine·Sebastian Rademacher, Britta J Eickholt
Dec 3, 2016·Frontiers in Cellular Neuroscience·Yu-Chih LinGene J Blatt
Oct 28, 2015·Translational Neurodegeneration·Danielle D FengXiqun Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Related Papers

Journal of Cellular Biochemistry
Li LiAlonzo H Ross
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Jacek JaworskiMorgan Sheng
Apoptosis : an International Journal on Programmed Cell Death
Y ZhuJ Krieglstein
Genesis : the Journal of Genetics and Development
Chang-Hyuk KwonLuis F Parada
© 2021 Meta ULC. All rights reserved