Correlation between systemic lupus erythematosus and cytomegalovirus infection detected by different methods

Clinical Rheumatology
Jing ChenXiangyang Xue

Abstract

Human cytomegalovirus (HCMV), a β-herpes virus subfamily member, leads to a lifelong, latent infection in most humans, but the correlation between HCMV infection and systemic lupus erythematosus (SLE) remains controversial. We analyzed the relevance of HCMV infection in SLE by analyzing the peripheral blood leukocytes (PBLs) and serum samples of 60 patients with SLE and 111 healthy individuals. HCMV genes UL55 and UL138 were detected in PBLs by polymerase chain reaction (PCR), and HCMV-specific serum IgG and IgM antibodies were investigated by enzyme-linked immunosorbent assay. The relationship between cellular HCMV infection in PBLs and common clinical indicators of SLE was further explored. Data indicated that the frequency of positive IgG and IgM anti-CMV antibodies was not significantly different in SLE patients and controls. However, compared to the healthy controls, the titers of IgG and IgM anti-CMV antibodies in SLE patients were significantly higher. The detection of cellular HCMV infection showed that almost all subjects were positive for UL138 gene in PBLs, but the positivity for UL55 gene was lower in PBLs. HCMV UL138 detection in PBLs was highly consistent with the frequency of the HCMV-specific IgG test and did no...Continue Reading

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Citations

May 12, 2017·The Korean Journal of Internal Medicine·Ju-Yang Jung, Chang-Hee Suh
Dec 8, 2017·Lupus Science & Medicine·Evan S VistaJudith A James
May 26, 2018·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Katia LinoJorge Reis Almeida
May 31, 2019·Critical Reviews in Microbiology·Hadi M Hussein, Elias A Rahal
Oct 6, 2020·Frontiers in Microbiology·Lele YeXiangyang Xue
Apr 25, 2020·Frontiers in Cellular and Infection Microbiology·Gangqiang GuoHuidi Zhang
Mar 7, 2021·Viruses·Marco QuagliaVincenzo Cantaluppi
May 1, 2021·International Journal of Molecular Sciences·Zhongjie YuBin Wang
Jun 13, 2021·Autoimmunity Reviews·Nurit Katz-Agranov, Gisele Zandman-Goddard
Aug 28, 2021·International Journal of Molecular Sciences·Rhiane MoodyMagdalena Plebanski
Aug 25, 2021·Journal of Medical Virology·Niloufar Yazdanpanah, Nima Rezaei

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