Correlation between target reinnervation and distribution of motor axons in the injured rat sciatic nerve

Journal of Neurotrauma
N Lago, Xavier Navarro

Abstract

Peripheral nerve injuries are rarely followed by complete return of function. Deficits are particularly important for motor function, resulting in paralysis and muscle atrophy. In different groups, the sciatic nerve was either crushed or transected and repaired by direct suture or by tube repair using silicone or collagen tubes. After 60 days, nerve regeneration was assessed by electrophysiological and functional tests, nerve morphology and immunohistochemistry against choline acetyltransferase (ChAT) for labeling motor axons. Suture and tube repair resulted in similar levels of muscle reinnervation, but significantly lower than after nerve crush. Recovery of walking track pattern was poor in all groups after nerve section. The numbers of regenerated myelinated fibers and of ChAT+ fibers were similar to control values after nerve crush, but increased after section and repair. The normal fascicular architecture and grouping of ChAT+ fibers were maintained after nerve crush, but lost after section and repair, where motor fibers were scattered within small regenerated fascicles throughout the nerve. The loss of fascicular organization was related to the deficient recovery of locomotor function. Thus, labeling of motor axons by ChA...Continue Reading

References

Jan 1, 1989·Plastic and Reconstructive Surgery·J R BainD A Hunter
Aug 1, 1987·Experimental Neurology·T M Brushart, W A Seiler
May 1, 1986·The Anatomical Record·H Schmalbruch
Apr 1, 1973·Journal of Neuropathology and Experimental Neurology·A J AguayoG M Bray
Jul 1, 1995·The Journal of Hand Surgery·T M BrushartG M Koschorke
Feb 1, 1997·Molecular Neurobiology·S Y Fu, T Gordon
Jul 9, 1998·Muscle & Nerve·C A MunroR Midha
Aug 14, 1998·Plastic and Reconstructive Surgery·S J MadorskyR L Crumley
Jan 22, 2000·The Journal of Hand Surgery·Y KawasakiS Park
Aug 13, 2002·Nature Neuroscience·Quyen T NguyenJeff W Lichtman
Dec 11, 2002·Journal of Neurochemistry·Maryline Simon-HaldiMelitta Schachner
Dec 20, 2002·Journal of Neurotrauma·Antoni Valero-Cabré, Xavier Navarro
Dec 4, 2003·Journal of the Peripheral Nervous System : JPNS·Göran Lundborg
Feb 11, 2004·Experimental Neurology·Atsushi NatsumeMarina Mata
Feb 28, 2004·Journal of Neurotrauma·Antoni Valero-CabréWolfram F Neiss
Feb 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Colin K FranzVictor F Rafuse

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Citations

Dec 31, 2010·Molecular Neurobiology·Bernardo Moreno-LópezDavid González-Forero
Jun 2, 2009·Plastic and Reconstructive Surgery·Björn BehrWolfgang Schneider
Sep 4, 2015·The European Journal of Neuroscience·Andres O'DalyThomas Brushart
Jun 5, 2013·The Journal of Surgical Research·Charles L Rodriguez-FeoWesley P Thayer
Apr 24, 2012·The Journal of Surgical Research·Kevin W SextonWesley P Thayer
Jun 15, 2007·Journal of the Peripheral Nervous System : JPNS·Natalia Lago, Xavier Navarro
Mar 22, 2007·Journal of the Peripheral Nervous System : JPNS·Clare M Galtrey, James W Fawcett
Feb 4, 2010·Journal of Neuroscience Research·Petrica-Adrian Panaite, Ibtissam Barakat-Walter
Jun 8, 2007·IEEE Transactions on Bio-medical Engineering·Natalia LagoXavier Navarro
Feb 7, 2007·IEEE Transactions on Bio-medical Engineering·Natalia LagoXavier Navarro
Nov 17, 2015·Hand : Official Journal of the American Association for Hand Surgery·Kevin W SextonWesley P Thayer
Feb 24, 2015·Restorative Neurology and Neuroscience·Laura Casals-DíazXavier Navarro
Mar 25, 2008·Neuroscience·Q G XuD W Zochodne
Apr 13, 2011·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Andrey Irintchev
May 23, 2012·Progress in Neurobiology·Ilary AllodiXavier Navarro
Apr 7, 2017·Journal of Neural Engineering·I Delgado-MartínezX Navarro
May 18, 2006·Journal of Neural Engineering·Anup RamachandranThomas Stieglitz
Apr 25, 2007·Journal of Neuroscience Research·Natalia LagoXavier Navarro
Jul 26, 2016·Frontiers in Neuroscience·Ignacio Delgado-MartínezXavier Navarro
Dec 23, 2016·Frontiers in Neuroscience·Matthew R MacEwanDaniel W Moran

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