PMID: 7388074Feb 1, 1980

Correlation between the distribution and inhibition constants of bacterial agmatinase inhibitors

Biokhimii︠a︡
V A Khramov

Abstract

A correlation between the distribution of chemical compounds in the water-non-polar solvent system and their inhibiting effect on bacterial agmatinase has been established. The correlation equation appears as lg(1/Ki)=algp0+C. The value of C is constant for homologous inhibitors but shows considerable variations upon a transition from the homologous row of alcohols to monoamines, diamines and guanidine alcanes. It is assumed that the value of C reflects the electrostatic interactions between the enzyme and ligand. Alternatively this value can be regarded as a factor of the ligand fitness into the enzyme active center. The correlation equations obtained for different homologous sequences allow to predict the inhibiting effect of still unknown homologues.

Related Concepts

Agmatinase
Alcohols
Amines
Diamines
Ligands
Plasma Protein Binding Capacity
Solvents
Structure-Activity Relationship
Ureohydrolases

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