Correlation Between the Expression of MicroRNA-301a-3p and the Proportion of Th17 Cells in Patients with Rheumatoid Arthritis

Inflammation
Xinyi TangShengjun Wang

Abstract

Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation and subsequent joint destruction. Previous studies have confirmed that Th17 cells play a critical role in the pathogenesis of RA. MicroRNA (miR)-301a-3p is a regulatory factor for Th17 cells differentiation that contributes to the pathogenesis of autoimmune diseases. The purposes of this study were to identify the alteration of Th17 cells and analyze the correlation between the expression of the miR-301a-3p and the proportion of Th17 cells in RA patients. The results showed that the frequency of Th17 cells and the expression of transcription factors (RORγt and STAT3) significantly increased in the peripheral blood mononuclear cells (PBMCs) from RA patients, and the associated proinflammatory cytokines were also upregulated. We also observed that the expression of protein inhibitor of activated STAT3 (PIAS3), the main cellular inhibitor of STAT3, was attenuated in RA patients and negatively correlated with the percentage of Th17 cells in RA. Interestingly, miR-301a-3p, an inhibitor of PIAS3 expression, was overexpressed in the PBMCs from RA patients and positively correlated with the frequency of Th17 cells in patients with RA. Taken together, these data...Continue Reading

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Citations

Sep 18, 2016·Autoimmunity Reviews·Ji-Qing ChenMargit Zeher
Aug 15, 2019·International Reviews of Immunology·Suyasha Roy, Amit Awasthi
Jan 13, 2018·The Journal of Clinical Endocrinology and Metabolism·Rebeca Martínez-HernándezMónica Marazuela
Jan 23, 2020·Journal of Clinical Medicine·Carolina LavozMarta Ruiz-Ortega
Jun 24, 2020·Cell Biochemistry and Function·Ying YangQuan Du
Mar 20, 2020·International Journal of Molecular Sciences·Chary Lopez-PedreraCarlos Pérez-Sánchez
Aug 12, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohammad TaheriSoudeh Ghafouri-Fard

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