Correlation between the genetic diversity and variation of total phenolic acids contents in Fructus Xanthii from different populations in China

Biomedical Chromatography : BMC
Ting HanLu-Ping Qin

Abstract

Fructus Xanthii (Cang-Er-Zi) is a traditional Chinese medicine that is used in curing nasal diseases and headache according to the Chinese Pharmacopoeia. For the effective quality control of its medicinal values, reflected by chemical variation patterns, in addition to the relationship with genetic diversity, analyses based on UV spectrophotometry, HPLC fingerprinting and inter-simple sequence repeat (ISSR) molecular markers were carried out, involving 16 Xanthium populations from different locations in China. The HPLC data showed considerable variation of chemical constituents among the 16 Xanthium populations, and they were classified to three chemotypes by hierarchical clustering analysis. Abundant genetic diversity was detected among the Xanthium populations, which were also clustered into three groups based on their ISSR data and varied according to different species. Combining the genetic divergence and chemical differences showed an important result that, in the two chemotypes, the higher contents of total phenolic acids (TPA) in Fructus Xanthii showed greater genetic diversity (I). We suggest that genetic diversity affects the contents of TPA. Since variable phenolic acid contents may affect therapeutic efficacy, it is ...Continue Reading

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Citations

Aug 23, 2011·Natural Product Research·Suqin KanHong Jiang
Jun 9, 2011·Critical Reviews in Biotechnology·Maryam SarwatPrem Shankar Srivastava
May 11, 2021·Physiology and Molecular Biology of Plants : an International Journal of Functional Plant Biology·Avinash KumarSoom Nath Raina

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