Correlation between the production of extracellular substances by type III group B streptococcal strains and virulence in a mouse model.

Infection and Immunity
D L DurhamD C Straus

Abstract

Twelve strains of serotype III group B streptococci (8 isolated from cases of neonatal disease, 3 isolated from asymptomatically colonized infants, and 1 laboratory reference strain) were examined for the vitro production of three potential extracellular virulence products: type-specific antigen, neuraminidase, and protease. In addition, virulence in a mouse model, expressed as 50% lethal dose, was determined for the 12 strains to determine whether a relationship existed between the production of any of the three extracellular products and virulence. Only production of extracellular type-specific antigen showed a correlation with virulence in the mouse model. The high producers of extracellular type-specific antigen were an average of 166-fold more virulent for mice than low producers of the same component. There was no correlation between virulence and either neuraminidase or protease production, nor was there a correlation between either of these two extracellular products and the levels of extracellular type-specific antigen. When levels of group B streptococci of each type (a high and low producer of extracellular type-specific antigen) in organs of infected mice were examined, comparable levels of organisms were found in t...Continue Reading

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Citations

Jul 1, 1993·The American Review of Respiratory Disease·J X LiJ B Philips
Jul 1, 1982·Infection and Immunity·P DomenicoD C Straus
Jan 1, 1991·Journal of Bacteriology·J J Maurer, S J Mattingly

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