Correlation between the pronucleus size and the potential for human single pronucleus zygotes to develop into blastocysts : 1PN zygotes with large pronuclei can expect an embryo development to the blastocyst stage that is similar to the development of 2PN zygotes

Journal of Assisted Reproduction and Genetics
Eri ArakiKazuyo Nishikawa

Abstract

In this study, we examined the correlation between pronucleus size and the potential for human single pronucleus (1PN) zygotes to develop into blastocysts after IVF and ICSI. This study included 112 patients who underwent a total of 112 cycles of IVF/ICSI. To evaluate embryo development, 1PN zygotes were compared with 2PN zygotes in the same IVF/ICSI cycle (control cycles) using time-lapse live embryo imaging. To assess the potential for blastocyst formation, cutoff values for pronuclear area and diameter were established through receiver operating characteristic curve analysis, after which 1PN zygotes were classified based on those cutoff values. Among 1PN zygotes cultured to day 5/6, the rate of embryo development was significantly lower than from 2PN zygotes. However, the rates of blastocyst formation and good quality blastocysts from 1PN zygotes with large pronuclear areas (≥ 710 μm2) or diameters (≥ 31 μm) were significantly higher than from 1PN zygotes with smaller pronuclear areas (≤ 509, 510-609, and 610-709 μm2) or diameters (≤ 24, 25-27,and 28-30 μm) (P < 0.01). Moreover, the results for 1PN zygotes with large pronuclei were similar to those for 2PN zygotes. The developmental potential of 1PN zygotes with large pronuc...Continue Reading

References

Mar 1, 1995·Biology of Reproduction·J LevronJ Cohen
Feb 12, 2005·Journal of Assisted Reproduction and Genetics·Daniel DasigAmin A Milki
Jul 28, 2005·Molecular Reproduction and Development·Anna Krukowska, Andrzej K Tarkowski
Jun 27, 2015·Journal of Assisted Reproduction and Genetics·Fumiaki ItoiYasutaka Murata
May 13, 2017·Journal of Assisted Reproduction and Genetics·S MateoM Boada

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Citations

Mar 12, 2020·Zygote : the Biology of Gametes and Early Embryos·Silvia MateoMontserrat Boada
Sep 5, 2020·Human Fertility : Journal of the British Fertility Society·Lei FuYuan Li
Apr 4, 2021·Journal of Assisted Reproduction and Genetics·Taketo InoueYoshiki Yamashita

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