PMID: 6969700Nov 1, 1980Paper

Correlation between the radiobiological oxygen constant, K, and the non-protein sulphydryl content of mammalian cells

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
B CullenL Révész

Abstract

The value of the radiobiological oxygen constant K has been found to depend on the concentration of non-protein sulphydryl (NPSH) within the cell. Cells in the exponential phase of growth have a higher concentration of NPSH and a higher value of K than cells in plateau phase. Binding NPSH with N-ethylmaleimide reduced the value of K and conversely, addition of NPSH as dithioerythritol increased the value of K. K also rises with the same time course as NPSH increases, when plateau phase cells are replated into fresh medium. These results support the hypothesis that free-SH groups within the cell compete with oxygen to react with radiation damaged molecules.

References

Jun 1, 1979·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J W HandS B Field
Feb 1, 1973·Journal of Cellular Physiology·J W Harris, S S Teng
Jul 1, 1969·Experimental Cell Research·J W Harris, H M Patt
Nov 3, 1956·Nature·T ALPER, P HOWARD-FLANDERS
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN

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Citations

Nov 1, 1983·The British Journal of Radiology·H Walker, B Cullen
May 1, 1981·The British Journal of Radiology·J LunecS Hornsey
May 1, 1981·The British Journal of Radiology·G H Whitehouse, C Sausman
Dec 1, 1981·The British Journal of Radiology·J DenekampF A Stewart
Jan 1, 1982·The British Journal of Radiology·F A Stewart, A Rojas
Apr 1, 1985·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·L Révész
Sep 1, 1986·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·S HornseyM J Hedges
Jan 1, 1987·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·H C Walker, B M Cullen
Jan 1, 1987·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·G SölenL Révész
Oct 1, 1985·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·D DebieuE P Malaise
Apr 1, 1983·International Journal of Radiation Oncology, Biology, Physics·F A StewartJ Denekamp
Dec 1, 1984·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A RojasJ Denekamp
Nov 1, 1984·European Journal of Cancer & Clinical Oncology·C ParkinsJ Denekamp
Nov 1, 1980·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·B M Cullen, H C Walker
Jan 1, 1988·Pharmacology & Therapeutics·J S RaseyJ C Livesey
Jan 1, 1990·Pharmacology & Therapeutics·E A Bump, J M Brown
Dec 1, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·D DebieuE P Malaise

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