Correlation between thoracic aorta 18F-natrium fluoride uptake and cardiovascular risk

World Journal of Radiology
Francesco FizGianmario Sambuceti

Abstract

To investigating the relationship between thoracic and cardiac (18)F-Natrium-Fluoride (18F-NaF) uptake, as a marker of ongoing calcification and cardiovascular risk factors. Seventy-eight patients (44 females, mean age 63, range 44-83) underwent whole body 18F-NaF positron emission tomography/computed tomography. Cardiovascular risk (CVR) was used to divide these patients in three categories: Low (LR), medium (MR) and high risk (HR). 18F-NaF uptake was measured by manually drawing volumes of interest on the ascending aorta, on the aortic arch, on the descending aorta and on the myocardium; average standardized uptake value was normalized for blood-pool, to obtain target-to-background ratio (TBR). Values from the three aortic segments were then averaged to obtain an index of the whole thoracic aorta. A significant difference in whole thoracic aorta TBR was detected between HR and LR (1.84 ± 0.76 vs 1.07 ± 0.3, P < 0.001), but also between MR and HR-LR (1.4 ± 0.4, P < 0.02 and P < 0.01, respectively). Significance of this TBR stratification strongly varied among thoracic aorta subsegments and the lowest P values were reached in the descending aorta (P < 0.01). Myocardial uptake provided an effective CVR classes stratification (P ...Continue Reading

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Citations

Jun 30, 2018·Journal of the American Heart Association·Ying WangYaming Li
Nov 28, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Poul F Høilund-CarlsenOke Gerke
Jul 12, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jamie W BellingeCarl J Schultz
Jan 4, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Leila S AraniAbass Alavi
Feb 26, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Francesco FizGianmario Sambuceti
Feb 24, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Michael T OsborneAhmed Tawakol

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