Jun 10, 2010

Correlation between TNF-alpha and IL-12p40-containing cytokines in silicosis

Toxicology and Industrial Health
E SlavovS Stanilova

Abstract

The aim of the present study was to investigate the correlation between tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-12p40-containing cytokines, in silicosis patients and healthy donors exposed to silica dust, in an attempt to clarify the reason for variety of clinical outcomes between humans with similar exposure history. Serum levels of TNF-alpha, IL-12p40, IL-12p70 and IL-23 in total group of 62 silicosis patients, 24 healthy donors with similar exposure history like patients and 19 healthy donors without exposure were determined by enzyme-linked-immunosorbent assay (ELISA) method. The serum level of TNF-alpha was significantly higher in healthy donors exposed to SiO(2) (22.4 +/- 11.1 pg/mL) in comparison with non-exposed healthy donors (14.8 +/- 8.8 pg/mL; p = 0.022) and similar to that in silicosis patients. In total, group of silicosis patients significantly elevated levels of TNF-alpha (20.9 +/- 12.9 vs. 14.8 +/- 8.8 pg/mL; p = 0.047) and IL-12p40 (94.5 +/- 51.6 pg/mL vs. 68.7 +/- 26.2 pg/mL; p = 0.029) compared to non-exposed healthy donors were observed. In addition, a strong positive correlation between TNF-alpha and IL-23 levels (r = 0.678; p = 0.022) and between TNF-alpha and IL-12p70 levels (r = 0.7...Continue Reading

Mentioned in this Paper

Interleukins
Tumor Necrosis Factor-alpha
Edodekin Alfa
Interleukin-23
Interleukin-12 Subunit p40
Interleukin-23 Binding Activity
Recombinant Interleukins
Cytokine
Silica Measurement
TNF gene

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