PMID: 8940671Oct 1, 1996Paper

Correlation between total and CD4 lymphocyte counts in HIV infection: not making the good an enemy of the not so perfect

International Journal of STD & AIDS
E J BeckA J Pinching

Abstract

The aim of this study was to assess the correlation and average cost of total lymphocyte count compared with CD4 count as a broad estimate of immunosuppression in HIV-1 infected individuals. Spearman's partial rank correlation were calculated between total lymphocyte count, absolute CD4 count and CD4 per cent stratified by stage of HIV-1 infection for routinely collected samples. Data were collected prospectively from a T cell-subset register combined with clinical data obtained retrospectively from case notes of HIV-infected patients managed at St Mary's Hospital, London 1982-1991. Costing data were obtained through a survey of the departments of haematology and immunology (1989/90 prices). The correlation between 1534 paired absolute lymphocyte count and CD4 lymphocyte count was found to be high (R = 0.76). When analysed by stage of HIV infection, the correlation increased from R = 0.64 for asymptomatic patients, to R = 0.72 for patients with symptomatic non-AIDS HIV infection and R = 0.73 for AIDS patients. Correlations between absolute lymphocyte count and CD4 per cent were considerably weaker: R = 0.41 all paired counts; R = 0.32 for asymptomatic patients; R = 0.25 for symptomatic non-AIDS patients; R = 0.32 for AIDS patie...Continue Reading

Citations

Aug 19, 2006·AIDS Research and Therapy·Yasmin PirzadaHaig Donabedian
Sep 3, 2011·Journal of Global Infectious Diseases·Srirangaraj Sreenivasan, Venkatesha Dasegowda
Oct 4, 2011·BMC Infectious Diseases·Nyawira GithinjiDorothy Mbori-Ngacha
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Aug 19, 2020·International Journal of Neural Systems·Jonathan DanAlexander Bertrand

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