PMID: 11311217Apr 20, 2001Paper

Correlation between total homocysteine, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in the serum of patients with myocardial infarction

Clinical Biochemistry
D QujeqL Hosini

Abstract

Determine the Low-density lipoprotein cholesterol (LDL-C), High-density lipoprotein cholesterol (HDL-C) and serum total homocysteine in myocardial infarction patients and control subjects. The study group consisted of 126 patients 67 male, and 59 females, aged 29-73 (mean 48.65 +/- 3.81) years. The entry criteria for the patient group was typical or atypical chest pain, unequivocal changes in the electrocardiogram. The control group consisted of 135 normal volunteers, 71 male and 64 females, age 21-63 (mean 42.73 +/- 5.79) years. Measurement of serum total homocysteine was performed using gas chromatography. Measurement of Low-density lipoprotein cholesterol, and High-density lipoprotein cholesterol were performed using spectrophotometer. Patients with myocardial infarction were found to have higher serum total homocysteine levels than controls, (P < 0.05). Serum total homocysteine levels were significantly correlated with low-density lipoprotein cholesterol and high-density lipoprotein cholesterol. There was a negative correlation between total homocysteine and HDL-C levels (P < 0.05, r = -0.93). There was a positive correlation between total homocysteine and LDL-C levels (P < 0.05, r = 0.98). The above mentioned findings sugg...Continue Reading

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