Correlation between translational and rotational kinematic abnormalities and osteoarthritis-like damage in two in vivo sheep injury models

Journal of Biomechanics
Mehdi ShekarforoushNigel G Shrive

Abstract

The relations between kinematic abnormalities and post traumatic osteoarthritis have not yet been clearly elucidated. This study was conducted to determine the finite helical axes parameters and the tibiofemoral translation vector in the knee joints of two surgically induced injury sheep models: anterior cruciate ligament and medial collateral ligament transection (ACL/MCL Tx) (n = 5) and lateral meniscectomy (n = 5). We hypothesized that morphological damage in the experimental joints would be correlated to alterations in these kinematic variables. There was no strong evidence that morphological damage to the joints 20 weeks post ACL/MCL transection or meniscectomy was correlated with alterations in the finite helical axes variables. Nevertheless, significant correlations were found between the morphological damage to the joints and the magnitude of the change in the translation vectors after ACL/MCL transection (significant correlations (p = 0.005) during stance and trends (p < 0.1) at all points analyzed during swing). It can be concluded that: (1) osteoarthritic-like morphological damage after ACL/MCL transection is more critically correlated to the absolute tibiofemoral translational change and (2) alterations in analyzed ...Continue Reading

Citations

Jan 19, 2019·Annals of Biomedical Engineering·Mehdi ShekarforoushNigel G Shrive
Jan 19, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jessica M MotherwellChristopher L Dearth

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