Correlation Between White Matter Lesions and Intelligence Quotient in Patients With Congenital Cytomegalovirus Infection

Pediatric Neurology
Yuji InabaKenichi Koike

Abstract

It is well known that congenital cytomegalovirus infection exhibits white matter and other types of lesions in magnetic resonance imaging (MRI), but little is known on the clinical significance of white matter lesions because they are also present in asymptomatic congenital cytomegalovirus infection. We investigated for relationships among white matter lesions, intelligence quotient, and other neurodevelopmental features. Nine children (five boys and four girls; mean age: 87.4 months, range: 63-127 months) with sensorineural hearing loss (five bilateral and four unilateral) had been diagnosed as having congenital cytomegalovirus infection by positive polymerase chain reaction findings of dried umbilical cords. They were evaluated for the presence of autistic features, tested using Wechsler Intelligence Scale for Children-Fourth Edition for intelligence quotient, and underwent brain MRI to measure white matter lesion localization and volume. At the time of MRI examination (mean age: 69.4 months, range: 19-92 months), white matter lesions were detected in eight of nine patients. Five subjects were diagnosed as having autism spectrum disorders. We observed increased white matter lesion volume was associated with lower intelligence...Continue Reading

References

Mar 5, 1992·The New England Journal of Medicine·K B FowlerC A Alford
Feb 1, 1992·The Pediatric Infectious Disease Journal·S B BoppanaC A Alford
Jun 1, 1984·Journal of Autism and Developmental Disorders·E G StubbsC P Williams
Sep 1, 1983·Journal of Autism and Developmental Disorders·P I Markowitz
Jan 5, 2005·Journal of Autism and Developmental Disorders·Thayne L SweetenChristopher J McDougle
Oct 26, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Scott D GrosseSheila C Dollard
Jan 25, 2008·Brain & Development·Yasuhiro SuzukiMasanori Nishikawa
Mar 11, 2011·Annals of Neurology·Gemma B NorthamTorsten Baldeweg
May 21, 2011·Pediatric Radiology·Renzo ManaraEzia Maria Ruga
Dec 18, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S E KimH W Lee

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Citations

Dec 1, 2017·Journal of Autism and Developmental Disorders·Kaori MaeyamaNoriyuki Nishimura
Sep 18, 2018·The Pediatric Infectious Disease Journal·Antonietta GiannattasioFrancesco Raimondi
May 18, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Giulia LucignaniDaniela Longo
Apr 4, 2017·Acta Oto-laryngologica·Shin-Ichi UsamiKizuki Watanabe

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