Correlation Does Not Imply Causation: Histone Methyltransferases, but Not Histone Methylation, SET the Stage for Enhancer Activation

Molecular Cell
Tim Pollex, Eileen E M Furlong

Abstract

Although H3K4me1 is a pervasive "mark" of enhancers, its functional requirement for enhancer activity remains unclear. In this issue of Molecular Cell, Dorighi et al. (2017) show that in some contexts, the methyltransferase complex, rather than the H3K4me1 mark, is required for gene expression.

Citations

Nov 22, 2018·Genome Research·Elena Vizcaya-MolinaMontserrat Corominas
Jun 28, 2018·Nature Reviews. Molecular Cell Biology·Vanja Haberle, Alexander Stark

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