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Correlation of 14C-griseofulvin metabolism in rat liver microsomes, isolated perfused rat livers, and in rats with bile duct cannulas

Drug Metabolism and Disposition : the Biological Fate of Chemicals

Jan 1, 1975

R L ChangChinlon Lin

PMID: 1223

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Abstract

The metabolism of 14C-griseofulvin has been compared in rat liver microsomes, isolated perfused rat livers, and rats with bile duct cannulas. In all three preparations, 4-desmethylgriseofulvin and 6-desmethylgriseofulvin were the major metabolites. The ratio of total 4-desmethylgriseofu...read more

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4-demethylgriseofulvin
Perfusion
Bile Duct Structure
6-demethylgriseofulvin
Bile Fluid
Entire Bile Duct
Portion of Urine
Metabolic Aspects
Catheterization
Metabolite
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  • Correlation of 14C-griseofulvin metabolism in rat liver microsomes, isolated perfused rat livers, and in rats with bile duct cannulas

    Drug Metabolism and Disposition : the Biological Fate of Chemicals

    Jan 1, 1975

    R L ChangChinlon Lin

    PMID: 1223

    DOI:

    Abstract

    The metabolism of 14C-griseofulvin has been compared in rat liver microsomes, isolated perfused rat livers, and rats with bile duct cannulas. In all three preparations, 4-desmethylgriseofulvin and 6-desmethylgriseofulvin were the major metabolites. The ratio of total 4-desmethylgriseofu...read more

    Mentioned in this Paper

    4-demethylgriseofulvin
    Perfusion
    Bile Duct Structure
    6-demethylgriseofulvin
    Bile Fluid

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