Correlation of 68Ga Ventilation-Perfusion PET/CT with Pulmonary Function Test Indices for Assessing Lung Function

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Pierre-Yves Le RouxMichael S Hofman

Abstract

Pulmonary function tests (PFTs) are routinely used to assess lung function, but they do not provide information about regional pulmonary dysfunction. We aimed to assess correlation of quantitative ventilation-perfusion (V/Q) PET/CT with PFT indices. Thirty patients underwent V/Q PET/CT and PFT. Respiration-gated images were acquired after inhalation of (68)Ga-carbon nanoparticles and administration of (68)Ga-macroaggregated albumin. Functional volumes were calculated by dividing the volume of normal ventilated and perfused (%NVQ), unmatched and matched defects by the total lung volume. These functional volumes were correlated with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, and diffusing capacity for carbon monoxide (DLCO). All functional volumes were significantly different in patients with chronic obstructive pulmonary disease (P < 0.05). FEV1/FVC and %NVQ had the highest correlation (r = 0.82). FEV1 was also best correlated with %NVQ (r = 0.64). DLCO was best correlated with the volume of unmatched defects (r = -0.55). Considering %NVQ only, a cutoff value of 90% correctly categorized 28 of 30 patients with or without significant pulmonary function impairment. Our study demonstrates strong ...Continue Reading

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Citations

Aug 22, 2016·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Pierre-Yves Le RouxMichael S Hofman
Sep 5, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Frédérique Blanc-BéguinPierre-Yves Le Roux
May 3, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Pierre-Yves Le RouxMichael S Hofman
Oct 12, 2017·EJNMMI Research·Pierre-Yves Le RouxMichael S Hofman

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