Correlation of ABO blood group with clinicopathologic characteristics of patients with esophageal squamous cell carcinoma

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
Tadahiro NozoeYoshihiko Maehara

Abstract

The aim of the current study was to determine the nvolvement of ABO blood group in clinicopathologic features in squamous cell carcinoma (SCC) of the esophagus, that has not previously been studied fully. Two hundred and eighty four consecutive patients with esophageal SCC were enrolled for the study. The relationship between patients' ABO blood group and the clinicopathologic features was analyzed. The proportion of poorly differentiated SCC among patients with blood group O was significantly lower than in those patients with other blood types (P = 0.001). The mean size of the tumors in patients with blood group AB was significantly larger than those in patients with other blood groups. The proportion of tumors associated with venous invasion was significantly higher in patients with blood type A than those of tumors in other blood types (P = 0.007). The TNM stages of tumors in blood group AB were found to be significantly more advanced (P = 0.036) than other groups. The functional significance of ABO blood group distribution might be associated with biological behavior of SCCs. However, it was found not to be a clinical predictor for the prognosis of the patients with esophageal SCC.

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Citations

Jun 2, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Debora Barreto TeresaChristiane Pienna Soares
Aug 10, 2010·PloS One·Jing XieJiali Han
Mar 1, 2012·World Journal of Gastroenterology : WJG·Yan GongMing-Zhou Guo
Feb 7, 2016·The Journal of Surgical Research·Ye-Qiong XuLi-Qing Qiu
Feb 4, 2009·Cancer Detection and Prevention·Alvaro L RoncoHugo Deneo-Pellegrini
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Qiwen BenZhaoshen Li
Apr 29, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Peng SunFeng-Hua Wang

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