PMID: 11909688Mar 23, 2002Paper

Correlation of age with in vivo expression of endothelial markers

Experimental Gerontology
Annette M MüllerKlaus-Michael Müller

Abstract

The importance of endothelial senescence as a pathogenetic factor in age-related vascular alterations has almost exclusively been studied in vitro. However, the in vitro-findings have rarely been compared with histomorphological changes in aging human tissue or in age-related degenerative diseases. Therefore, we compared the expression of the endothelial marker CD34 and the procoagulant protein von Willebrand factor (vWf) in lung endothelium by conventional immunohistochemistry and confocal laser scan microscopy (CLSM), taking the age of the patients into consideration. The staining reactions were statistically analysed by covariance analysis. With age the endothelial staining intensity of CD34 increased in arteries and veins, but decreased in arterioles, capillaries and venules. For vWf, on the contrary, the endothelial staining intensity increased with age in all types of vessels. CLSM confirmed a mosaic staining pattern. This study demonstrates age-associated phenotypical alterations of CD34 and vWf. Whether the down-regulation of CD34 correlates with an age-associated reduction of the angiogenetic properties of EC or an age-related over-expression of vWf as a relevant cofactor for the raised coagulatory activity and the inc...Continue Reading

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Citations

Apr 19, 2013·Biogerontology·F BonominiR Rezzani
Mar 25, 2004·Experimental Gerontology·P d'Alessio
Jan 29, 2008·The Journal of Sexual Medicine·Carla Costa, Pedro Vendeira
Jul 22, 2008·Pathology, Research and Practice·Martina C HerwigAnnette M Müller
Aug 3, 2016·European Journal of Immunology·Bandana SinghGausal A Khan
Sep 19, 2002·The Journal of Pathology·Annette M MüllerC James Kirkpatrick
Oct 20, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Marc P PusztaszeriFred T Bosman
Apr 12, 2005·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ender Arikan, Saniye Sen
Apr 15, 2003·The Journal of Pathology·Allan J McLeanDavid G Le Couteur
Apr 13, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Anahita MojiriNadia Jahroudi

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