Correlation of alpha 2 beta 1 integrin expression with histological type and hormonal receptor status in breast carcinomas

Pathology, Research and Practice
S LanzafameA Torrisi

Abstract

Interactions between cells and extracellular matrix are mediated in part by a family of alpha beta heterodimeric molecules known as integrins. Immunohistochemical studies have shown that benign hyperplastic/neoplastic mammary epithelium expressed high levels of alpha 2 beta 1 collagen/laminin receptor. In contrast, malignant cells of breast carcinoma exhibited marked diminuition or loss of the alpha 2 beta 1 integrin. A correlation has been suggested between the loss of the alpha 2 beta 1 expression and the increased invasiveness of neoplastic cells. This study investigated the expression of alpha 2 beta 1 integrin and its extracellular ligand collagen TV by using monoclonal antibodies on the cryostat section of 124 invasive mammary carcinomas. Two patterns of alpha 2 beta 1 immunoreactivity, i.e. pericellular and basolateral, were identified in breast carcinomas and correlated with their histological type. In most invasive ductal carcinomas of no special type (NOS), integrin staining tended to decrease in both pericellular and basolateral aspects. Loss of basolateral staining for alpha 2 beta 1 integrin corresponded closely to the loss of immunoreactivity for collagen IV. Mucinous and medullary carcinomas showed strongly alpha...Continue Reading

Citations

Sep 22, 2018·Scientific Reports·Ayman M IbrahimTorsten Stein
Nov 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·Carola FörsterJan-Ake Gustafsson
Dec 7, 2007·International Journal of Radiation Biology·Nils Cordes, Catherine C Park
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