Correlation of amyloid PET ligand florbetapir F 18 binding with Aβ aggregation and neuritic plaque deposition in postmortem brain tissue.

Alzheimer Disease and Associated Disorders
Seok Rye ChoiChristopher M Clark

Abstract

Florbetapir F 18 (F-AV-45) is a positron emission tomography imaging ligand for the detection of amyloid aggregation associated with Alzheimer disease. Earlier data showed that florbetapir F 18 binds with high affinity to β-amyloid (Aβ) plaques in human brain homogenates (Kd=3.7 nM) and has favorable imaging pharmacokinetic properties, including rapid brain penetration and washout. This study used human autopsy brain tissue to evaluate the correlation between in vitro florbetapir F 18 binding and Aβ density measured by established neuropathologic methods. The localization and density of florbetapir F 18 binding in frozen and formalin-fixed paraffin-embedded sections of postmortem brain tissue from 40 patients with a varying degree of neurodegenerative pathology was assessed by standard florbetapir F 18 autoradiography and correlated with the localization and density of Aβ identified by silver staining, thioflavin S staining, and immunohistochemistry. There were strong quantitative correlations between florbetapir F 18 tissue binding and both Aβ plaques identified by light microscopy (Silver staining and thioflavin S fluorescence) and by immunohistochemical measurements of Aβ using 3 antibodies recognizing different epitopes of ...Continue Reading

References

Jan 1, 1989·Acta Neuropathologica·H M WisniewskiK S Kim
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·I Grundke-IqbalH M Wisniewski
Jul 1, 1994·Journal of Neuropathology and Experimental Neurology·L C WalkerD B Schenk
Aug 19, 2003·Archives of Biochemistry and Biophysics·Harry LeVine
May 12, 2004·Current Pharmaceutical Design·C A MathisW E Klunk
Oct 29, 2005·Nuclear Medicine and Biology·Wei ZhangHank F Kung
Nov 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William E KlunkChester A Mathis
Jun 8, 2006·Annual Review of Biochemistry·Fabrizio Chiti, Christopher M Dobson
Nov 4, 2006·Science·Erik D Roberson, Lennart Mucke
Jan 11, 2007·Nuclear Medicine and Biology·Wei ZhangHank F Kung
Aug 19, 2007·Brain : a Journal of Neurology·A LockhartT G Beach
Jan 29, 2008·Current Alzheimer Research·Gary C LookGrant A Krafft
Mar 15, 2008·Brain : a Journal of Neurology·Milos D IkonomovicSteven T DeKosky
Mar 19, 2008·Cell and Tissue Banking·Thomas G BeachJoseph Rogers
Jun 5, 2008·Brain : a Journal of Neurology·Geraint Rees
Jun 25, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Simone P ZehntnerBarry J Bedell
Nov 8, 2008·Current Opinion in Neurology·William E Klunk, Chester A Mathis
Feb 20, 2009·Journal of Neurochemistry·Paul W ThompsonAndrew Lockhart
Apr 18, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Michel KooleKoen Van Laere
Apr 21, 2009·Journal of Cellular and Molecular Medicine·Prashant R BharadwajIan G Macreadie
Apr 22, 2009·Acta Neuropathologica·Charles DuyckaertsMarie-Claude Potier
Sep 15, 2009·Journal of Alzheimer's Disease : JAD·Julie A SchneiderDavid A Bennett
Oct 20, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Seok Rye ChoiHank F Kung
Jan 29, 2010·The New England Journal of Medicine·Henry W Querfurth, Frank M LaFerla

❮ Previous
Next ❯

Citations

May 3, 2013·Current Psychiatry Reports·Abhisek C Khandai, Howard J Aizenstein
Aug 22, 2013·Translational Psychiatry·N MattssonUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 12, 2013·TheScientificWorldJournal·Benoît Leclerc, Abedelnasser Abulrob
Mar 8, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Valle Camacho, Alberto Lleó
Feb 1, 2013·Neurodegenerative Disease Management·Joshua D GrillJeffrey M Burns
Feb 8, 2014·AJNR. American Journal of Neuroradiology·K Kantarci
May 2, 2013·Neurobiology of Disease·Jonathan J SabbaghJeffrey L Cummings
Sep 17, 2014·The Journal of Nutrition, Health & Aging·P SaidlitzJ Delrieu
Dec 12, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Kie HonjoNicolaas P L G Verhoeff
Nov 12, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Stefan TeipelUNKNOWN Alzheimer´s Disease Neuroimaging Initiative
Jan 16, 2016·Alzheimer's Research & Therapy·Sepideh ShokouhiUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Oct 3, 2012·Seminars in Nuclear Medicine·Chester A MathisWilliam E Klunk
Oct 18, 2016·Brain Informatics·Qian ZhaoYun Zhou
Apr 16, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zsolt Cselényi, Lars Farde
May 9, 2015·European Journal of Nuclear Medicine and Molecular Imaging·P PayouxS Andrieu
Jun 22, 2016·Brain Pathology·Sepideh ShokouhiUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 5, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Dietmar Rudolf ThalChristopher Buckley
Mar 23, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Daniel FelskyAristotle N Voineskos
Feb 2, 2018·Anesthesiology·Rebecca Y KlingerUNKNOWN Neurologic Outcomes Research Group (NORG)
Jun 28, 2018·AJR. American Journal of Roentgenology·Katherine ZukotynskiSandra E Black
Aug 18, 2018·International Journal of Molecular Sciences·Daniel Miguel Ángel Villalobos AcostaMartha Cecilia Rosales Hernández
Oct 27, 2017·F1000Research·Leonardo IaccarinoDaniela Perani
Apr 11, 2019·American Journal of Alzheimer's Disease and Other Dementias·Miwako TakahashiToshimitsu Momose
May 6, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Kaj BlennowHarald Hampel
Jun 25, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Daniela PeraniUNKNOWN IMBI Project
Nov 8, 2019·Journal of Labelled Compounds & Radiopharmaceuticals·Lifang ZhangHank F Kung
Jun 7, 2019·Neurology·Gérard N Bischof, Heidi I L Jacobs
Jun 27, 2019·Neurology·Julia NeitzelUNKNOWN Alzheimer's Disease Neuroimaging Initiative (ADNI)
Jul 7, 2012·Current Opinion in Neurology·Joseph C MasdeuKaren F Berman
Aug 9, 2016·Movement Disorders Clinical Practice·Rizwan S AkhtarAndrew D Siderowf
Dec 7, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Yiu Ming KhorSharmila Dorbala
Jan 27, 2015·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Thomas G BeachMarwan N Sabbagh
May 18, 2016·PloS One·Xueqi ChenUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jul 19, 2017·JAD Reports·Nasim Sheikh-BahaeiJonathan Harvey Gillard
Mar 7, 2020·Alzheimer's Research & Therapy·Sanka AmadoruChristopher C Rowe
Jan 11, 2017·Journal of Neuropathology and Experimental Neurology·Pengcheng HanJiong Shi
Oct 1, 2015·Dementia & Neuropsychologia·Chetsadaporn PromteangtrongCarlos Buchpiguel
Apr 2, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Shanker SwaminathanUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Nov 15, 2017·Current Treatment Options in Neurology·Nasim Sheikh-BahaeiAimee L Pierce

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