PMID: 11955817Apr 17, 2002Paper

Correlation of aqueous solubility of salts of benzylamine with experimentally and theoretically derived parameters. A multivariate data analysis approach

International Journal of Pharmaceutics
Henrik ParshadClaus Larsen

Abstract

Twenty two salts of benzylamine and p-substituted benzoic acids were prepared and characterized. The p-substituent was varied with regard to electronic, hydrophobic, and steric effects as well as hydrogen bonding potential. A multivariate data analysis was used to describe the relationship between the aqueous solubility of the salts and experimentally determined physicochemical parameters and theoretically derived molecular descriptors. The model, based on all descriptors, gave R(2)=0.86 and Q(2)=0.72. The most significant descriptors exhibiting VIP (variance of importance) values above 1.0 were intrinsic dissolution rate, intrinsic solubility of the unionized acids (S(0)), Hansch's hydrophobic parameter, Charton's steric parameter and molecular weight (MW). Statistically good models for predicting solubility of a selected test set were obtained by using simple models consisting of a few descriptors only: (i) Charton, Hansch and MW (R(2)=0.73; Q(2)=0.70), and (ii) Charton and S(0) (R(2)=0.74; Q(2)=0.72).

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Citations

Apr 15, 2004·International Journal of Pharmaceutics·Vimon Tantishaiyakul
Jul 30, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Henrik ParshadClaus Larsen
Apr 6, 2006·The AAPS Journal·Stephen R Johnson, Weifan Zheng
Jul 10, 2007·Advanced Drug Delivery Reviews·Abu T M Serajuddin
Feb 7, 2013·Pharmacological Reviews·Hywel D WilliamsChristopher J H Porter

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