Correlation of baseline plasminogen activator inhibitor activity with patency of the infarct artery after thrombolytic therapy in acute myocardial infarction

The American Journal of Cardiology
G I BarbashU Seligsohn

Abstract

Increased levels of plasminogen activator inhibitor (PAI) have recently been described in patients with acute myocardial infarction (AMI). To correlate PAI levels to patency of infarct arteries after thrombolytic therapy with recombinant tissue-type plasminogen activator (rt-PA), 125 consecutive patients with AMI were examined. Blood levels of fibrinogen, plasminogen, tissue plasminogen activator (t-PA) and PAI were measured before treatment initiation, 10 minutes after completion of rt-PA infusion and 24 and 48 hours after treatment. Coronary angiography, performed in all patients 72 hours after beginning rt-PA infusion, revealed patent infarct arteries in 97 patients and occluded infarct arteries in 28 patients. Pretreatment levels of PAI were significantly higher in patients with occluded infarct arteries (18.0 +/- 11.5 vs 10.5 +/- 9.3 IU/ml, p less than 0.01). Conceivably, higher levels of PAI may interfere with the natural thrombolytic process and make pharmacologic thrombolytic intervention less effective.

References

Aug 31, 1985·British Medical Journal·J A ParamoF van de Werf
Oct 16, 1980·The New England Journal of Medicine·M A DeWoodH T Lang

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Citations

Jan 1, 1993·International Journal of Clinical & Laboratory Research·D PriscoG F Gensini
Jul 31, 2008·Journal of Thrombosis and Thrombolysis·Vincent M G MaherFelicita Andreotti
Nov 7, 2009·Journal of Thrombosis and Thrombolysis·Zuzana MotovskaJan Kvasnicka
Feb 1, 1992·Journal of the American College of Cardiology·Y ShiA Zalewski
Mar 15, 1996·Journal of the American College of Cardiology·T KonoA Fujiwara
Jun 1, 1992·Australian and New Zealand Journal of Medicine·R M NorrisH D White
Jul 1, 1994·Acta Paediatrica·A BallinD Meytes
Apr 1, 1993·Thrombosis Research·A Hamsten
Oct 15, 1996·The American Journal of Cardiology·R J KatzC Kessler
Feb 8, 2005·The American Journal of Cardiology·Teruo InoueKoichi Node
Jun 17, 2000·Baillière's Best Practice & Research. Clinical Haematology·N A Booth
Nov 1, 1991·Progress in Cardiovascular Diseases·B Wiman, A Hamsten
Mar 1, 1995·Circulation·E Braunwald
Jul 19, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·L OlivottiC Brunelli
Nov 21, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·A Sinkovic
Jul 3, 2004·Vascular Medicine·Dorairaj Prabhakaran, Sonia S Anand
Nov 14, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Stephen C NichollsWayne L Chandler
Jan 1, 1992·Circulation·V J Marder
Sep 1, 1994·Baillière's Clinical Haematology·N A Booth, B Bennett

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