Jul 1, 1976

Correlation of behavioural inhibition or excitation produced by bromocriptine with changes in brain catecholamine turnover

The Journal of Pharmacy and Pharmacology
S R SniderS Fahn

Abstract

The dopamine agonist, bromocriptine, produced either inhibition or stimulation of motor behaviour in rats depending upon the dose and time after administration. Stimulation of motor activity occurred only with high doses after a 1-2 h delay. Both inhibition and stimulation were associated with decreased turnover of dopamine in the brain. Release of noradrenaline in brain and noradrenaline plus adrenaline in adrenal varied with motor activity. It is suggested that low doses of bromocriptine inhibit behaviour by activating an inhibitory presynaptic receptor, resulting in reduced synthesis and release of dopamine, whilst high doses cause behavioural excitation by activating the post-synaptic dopamine receptor.

Mentioned in this Paper

Behavior, Animal
Sympathetic Nervous System
Brain
Dopamine Beta Hydroxylase Deficiency
Parlodel
Ergoline
Catecholamines
Methyltyrosines

About this Paper

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