Correlation of brain levels of progesterone and dehydroepiandrosterone with neurological recovery after traumatic brain injury in female mice

Psychoneuroendocrinology
Ana Belen Lopez-RodriguezLuis M Garcia-Segura

Abstract

Traumatic brain injury (TBI) is an important cause of disability in humans. Neuroactive steroids, such as progesterone and dehydroepiandrosterone (DHEA), are neuroprotective in TBI models. However in order to design potential neuroprotective strategies based on neuroactive steroids it is important to determine whether its brain levels are altered by TBI. In this study we have used a weight-drop model of TBI in young adult female mice to determine the levels of neuroactive steroids in the brain and plasma at 24h, 72 h and 2 weeks after injury. We have also analyzed whether the levels of neuroactive steroids after TBI correlated with the neurological score of the animals. TBI caused neurological deficit detectable at 24 and 72 h, which recovered by 2 weeks after injury. Brain levels of progesterone, tetrahydroprogesterone (THP), isopregnanolone and 17β-estradiol were decreased 24h, 72 h and 2 weeks after TBI. DHEA and brain testosterone levels presented a transient decrease at 24h after lesion. Brain levels of progesterone and DHEA showed a positive correlation with neurological recovery. Plasma analyses showed that progesterone was decreased 72 h after lesion but, in contrast with brain progesterone, its levels did not correlate...Continue Reading

References

Mar 4, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P F StahelM C Morganti-Kossmann
May 15, 2001·Journal of Neurobiology·I AzcoitiaL M Garcia-Segura
Sep 6, 2001·The Journal of Trauma·F MassonUNKNOWN Aquitaine Group for Severe Brain Injuries Study
Sep 27, 2003·Epilepsia·John Bruns, W Allen Hauser
Feb 14, 2004·Journal of Neuroendocrinology·I CirizaL M Garcia-Segura
May 10, 2005·European Journal of Endocrinology·Marta BondanelliEttore C degli Uberti
Jan 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Ibolja Cernak
Oct 3, 2006·Annals of Emergency Medicine·David W WrightDonald G Stein
Aug 3, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A MilmanC G Pick
Nov 27, 2007·Cellular and Molecular Life Sciences : CMLS·R C MelcangiA G Mensah-Nyagan
May 2, 2008·Critical Care : the Official Journal of the Critical Care Forum·Guomin XiaoZhenhui Lu
Mar 24, 2009·The Mount Sinai Journal of Medicine, New York·Mark W Greve, Brian J Zink
May 9, 2009·Hormones and Behavior·Marzia PesaresiRoberto Cosimo Melcangi
Aug 29, 2009·Nature Protocols·Michael A FlierlEsther Shohami
May 25, 2010·Journal of Neurochemistry·Donatella CarusoRoberto C Melcangi
Jun 18, 2010·Canadian Journal of Physiology and Pharmacology·Nader ShahrokhiNouzar Nakhaee
Oct 12, 2010·Journal of Neurotrauma·Anahid MirzatoniBarney A Schlinger
Sep 14, 2011·Journal of Neurotrauma·Eleni SiopiMehrnaz Jafarian-Tehrani
Feb 3, 2012·Translational Stroke Research·Adam ChodobskiJoanna Szmydynger-Chodobska
Jan 1, 2011·Frontiers in Endocrinology·Kinga K BorowiczStanislaw J Czuczwar
Nov 22, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Vassilios Papadopoulos, Walter L Miller
Jan 19, 2013·Nature Reviews. Neuroscience·Ye XiongMichael Chopp
Feb 11, 2014·Molecular and Cellular Endocrinology·Quan-Guang ZhangDarrell W Brann
Apr 29, 2014·Journal of Neurochemistry·Donatella CarusoRoberto Cosimo Melcangi
Dec 11, 2014·The New England Journal of Medicine·David W WrightUNKNOWN NETT Investigators

❮ Previous
Next ❯

Citations

Dec 15, 2015·Neuroscience and Biobehavioral Reviews·Roberto C MelcangiLuis M Garcia-Segura
Nov 26, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Michael SchumacherRachida Guennoun
Mar 24, 2016·Experimental Neurology·Ana Belen Lopez-RodriguezMaria-Paz Viveros
Apr 7, 2016·Progress in Neurobiology·Bruno Dutra ArboMaria Flavia Ribeiro
Jun 4, 2015·Glia·Estefania Acaz-FonsecaM Angeles Arevalo
Jun 11, 2016·Progress in Neurobiology·Estefanía Acaz-FonsecaGeorge E Barreto
Feb 23, 2019·CNS Drugs·Ariela FriederKristina M Deligiannidis
Dec 11, 2019·Scientific Reports·Alex P Di BattistaMichael G Hutchison
Jan 22, 2019·Journal of Neurotrauma·Colleen N BodnarAdam D Bachstetter
Sep 1, 2015·Expert Review of Endocrinology & Metabolism·Philippe Liere, Michael Schumacher
Jul 30, 2020·International Journal of Molecular Sciences·Rachida Guennoun
Dec 29, 2020·Frontiers in Cell and Developmental Biology·Hazel Y StevensKrishnendu Roy
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ishtiaq AhmedQingyou Liu
Jul 1, 2021·Journal of Neuroendocrinology·Silvia DiviccaroRoberto Cosimo Melcangi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.