Correlation of Brain Neuropeptide (Nesfatin-1 and Orexin-A) Concentrations with Anthropometric and Biochemical Parameters in Malnourished Children

Journal of Clinical Research in Pediatric Endocrinology
Feyza Ustabaş KahramanRuşen Dündaröz

Abstract

Malnutrition continues to be a leading cause of stunted growth in many countries. This study aimed to investigate serum nesfatin-1 and orexin-A levels in underweight children and the potential correlations of these levels with anthropometric and nutritional parameters. The study enrolled 44 prepubertal children (between 2 and 12 years of age) with thinness grades of 1-3 and 41 healthy age- and gender-matched children. The demographic, clinical and laboratory parameters including nesfatin-1 and orexin-A concentrations were compared between the two groups. The correlations of nesfatin-1 and orexin-A with biochemical and anthropometric parameters were investigated. The receiver operating characteristic (ROC) analysis were also performed for evaluating nesfatin-1 and orexin-A in distinguishing children with malnutrition from healthy controls. Thyroid-stimulating hormone, vitamin B12 and insulin levels were significantly lower in the study group than controls (p=0.001, p=0.049 and p=0.033, respectively). Mean nesfatin-1 levels in the malnourished group was also significantly lower compared to the healthy controls (3871.2 ± 1608.8 vs. 5515.0 ± 3816.4 pg/mL, p=0.012). No significant difference was observed in the orexin-A levels betwe...Continue Reading

Citations

Oct 12, 2018·Journal of the Endocrine Society·Martha A Schalla, Andreas Stengel
Sep 12, 2019·Pediatric Obesity·Olaya de DiosCarmen Garcés
Apr 2, 2020·Peptides·Martha A SchallaAndreas Stengel
Apr 20, 2021·The Journal of Obstetrics and Gynaecology Research·Fatemeh RazaviniaShayesteh Jahanfar
Aug 1, 2021·General and Comparative Endocrinology·Krittika DotaniaUmesh Rai

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

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